A Direct, One Step Synthesis of Imidazoles from Imines and Acid Chlorides: A Palladium Catalyzed Multicomponent Coupling Approach

A palladium-catalyzed one-step synthesis of imidazoles from imines and acid chlorides is described. A plausible mechanism for this multicomponent reaction is provided, which explains the selective incorporation of two different imines into the final product with perfect regiocontrol. Overall, this c...

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Veröffentlicht in:	Journal of the American Chemical Society 2006-05, Vol.128 (18), p.6050-6051
Hauptverfasser:	Siamaki, Ali R, Arndtsen, Bruce A
Format:	Artikel
Sprache:	eng
Schlagworte:	Carboxylic Acids - chemistry Catalysis Chemistry Chlorides - chemistry Exact sciences and technology Imidazoles - chemical synthesis Imines - chemistry Kinetics and mechanisms Organic chemistry Palladium - chemistry Reactivity and mechanisms
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Beschreibung
Zusammenfassung:	A palladium-catalyzed one-step synthesis of imidazoles from imines and acid chlorides is described. A plausible mechanism for this multicomponent reaction is provided, which explains the selective incorporation of two different imines into the final product with perfect regiocontrol. Overall, this catalytic process provides a modular method to prepare imidazoles directly from building blocks that are all either commercially available or readily generated.
ISSN:	0002-7863 1520-5126
DOI:	10.1021/ja060705m