spiro-Mamakone A: A Unique Relative of the Spirobisnaphthalene Class of Compounds

A spirobisnaphthalene derivative with a new spiro-nonadiene skeleton, spiro-mamakone A (1), has been isolated from the extract of a cultured nonsporulating fungal endophyte derived from the New Zealand native tree Knightia excelsa (rewarewa). The carbon skeleton of spiro-mamakone A represents a new...

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Veröffentlicht in:	Organic letters 2006-05, Vol.8 (10), p.2059-2061
Hauptverfasser:	van der Sar, Sonia A, Blunt, John W, Munro, Murray H. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Infective Agents - chemistry Anti-Infective Agents - isolation & purification Anti-Infective Agents - pharmacology Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - isolation & purification Antibiotics, Antineoplastic - pharmacology Bacillus subtilis - drug effects Cladosporium - drug effects Drug Screening Assays, Antitumor Fungi - chemistry Leukemia P388 Microbial Sensitivity Tests Molecular Structure Naphthalenes - chemistry Naphthalenes - isolation & purification Naphthalenes - pharmacology New Zealand Spiro Compounds - chemistry Spiro Compounds - isolation & purification Spiro Compounds - pharmacology Trees Trichophyton - drug effects
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Zusammenfassung:	A spirobisnaphthalene derivative with a new spiro-nonadiene skeleton, spiro-mamakone A (1), has been isolated from the extract of a cultured nonsporulating fungal endophyte derived from the New Zealand native tree Knightia excelsa (rewarewa). The carbon skeleton of spiro-mamakone A represents a new structural entity and an intriguing addition to the structurally diverse spirobisnaphthalene group of compounds. spiro-Mamakone A is potently cytotoxic and is also antimicrobial.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol060434k