Alterations in serum levels of trace elements in tuberculosis and HIV infections

Objective: To evaluate serum concentrations of trace elements in tuberculosis (TB) patients with or with out human immunodeficiency virus (HIV) coinfection before and after anti-TB chemotherapy. Subjects: A total of 155 TB patients, 74 of which were coinfected with HIV, and 31 healthy controls from...

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Veröffentlicht in:	European journal of clinical nutrition 2006-05, Vol.60 (5), p.580-586
Hauptverfasser:	Kassu, A, Yabutani, T, Mahmud, Z.H, Mohammad, A, Nguyen, N, Huong, B.T.M, Hailemariam, G, Diro, E, Ayele, B, Wondmikun, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antitubercular Agents - therapeutic use Bacterial diseases Biological and medical sciences blood composition Blood products blood serum Chemotherapy Clinical Nutrition coinfections Copper Copper - analysis Copper - blood dietary minerals Epidemiology Ethiopia Female HIV HIV infections HIV Infections - blood HIV Infections - complications Human bacterial diseases human diseases Human immunodeficiency virus Human viral diseases Humans Inductively coupled plasma mass spectrometry Infectious diseases Internal Medicine Iron Iron - analysis Iron - blood Male Mass Spectrometry Medical sciences Medicine Medicine & Public Health Metabolic Diseases Nutrition Nutritional Status original-article patients Public Health Selenium Selenium - analysis Selenium - blood Serum levels Supplements Trace elements Trace Elements - analysis Trace Elements - blood Tuberculosis Tuberculosis - blood Tuberculosis - complications Tuberculosis - drug therapy Tuberculosis and atypical mycobacterial infections Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Zinc Zinc - analysis Zinc - blood
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Zusammenfassung:	Objective: To evaluate serum concentrations of trace elements in tuberculosis (TB) patients with or with out human immunodeficiency virus (HIV) coinfection before and after anti-TB chemotherapy. Subjects: A total of 155 TB patients, 74 of which were coinfected with HIV, and 31 healthy controls from Gondar, Ethiopia. Methods: Serum levels of copper, zinc, selenium and iron were determined using an inductively coupled plasma mass spectrometer from all subjects at baseline and from 44 TB patients (22 with HIV coinfection) at the end of an intensive phase of anti-TB chemotherapy. Results: Compared with the control group, the concentrations of iron, zinc and selenium were significantly lower (P
ISSN:	0954-3007 1476-5640
DOI:	10.1038/sj.ejcn.1602352