Changes in distribution patterns of integrins in endometrium in copper T380 intrauterine device users
Intrauterine contraception is the most cost-effective reversible method of contraception today, but its mechanism of action is not well understood. Our objective was to investigate immunohistochemical distribution patterns of αv, α3, β1 integrins in women using a copper T380 intrauterine device (IUD...
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| Veröffentlicht in: | Acta histochemica 2005-01, Vol.107 (2), p.95-103 |
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| container_title | Acta histochemica |
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| creator | Oruç, Semra Vatansever, H. Seda Karaer, Öznur Eskicioğlu, Fatma Narlıkuyu, Burcu |
| description | Intrauterine contraception is the most cost-effective reversible method of contraception today, but its mechanism of action is not well understood. Our objective was to investigate immunohistochemical distribution patterns of
αv,
α3,
β1 integrins in women using a copper T380 intrauterine device (IUD) for different periods of time to obtain insight into the role of integrins in intrauterine contraception. Endometrial biopsies were obtained from patients using T Cu380A IUD in follicular and luteal phases and in menopausal women grouped according to the period of time of IUD use (group 1: |
| doi_str_mv | 10.1016/j.acthis.2005.01.001 |
| format | Article |
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αv,
α3,
β1 integrins in women using a copper T380 intrauterine device (IUD) for different periods of time to obtain insight into the role of integrins in intrauterine contraception. Endometrial biopsies were obtained from patients using T Cu380A IUD in follicular and luteal phases and in menopausal women grouped according to the period of time of IUD use (group 1: <3 year, and group 2: ⩾3 years). Each group consisted of 10 patients, with a total number of 60 patients. Labelling intensity of all integrins, except for
β1 which increased in the follicular phase, were decreased in women who used IUD for ⩾3 years when compared with group 1 in the follicular and luteal phases and in the menopause. We conclude that long-term use of IUD affects integrin expression in endometrium not only in follicular and luteal phases of premenopausal women but also in postmenopausal women. Copper IUD can inhibit binding of integrins to the extracellular matrix and it may cause inhibition of the implantation stage, which is crucial for pregnancy.</description><identifier>ISSN: 0065-1281</identifier><identifier>EISSN: 1618-0372</identifier><identifier>DOI: 10.1016/j.acthis.2005.01.001</identifier><identifier>PMID: 15950052</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Contraception ; Endometrium ; Endometrium - cytology ; Endometrium - metabolism ; Female ; Follicular Phase - metabolism ; Humans ; Immunohistochemistry ; Implantation ; Integrin alpha3 - metabolism ; Integrin alphaV - metabolism ; Integrin beta1 - metabolism ; Integrins ; Intrauterine Devices, Copper ; IUD ; Luteal Phase - metabolism ; Menopause - metabolism</subject><ispartof>Acta histochemica, 2005-01, Vol.107 (2), p.95-103</ispartof><rights>2005 Elsevier GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-a07edf007af9faf83664c68c7419d337860ca32cc7a5fee47d1434433c6f0d4d3</citedby><cites>FETCH-LOGICAL-c391t-a07edf007af9faf83664c68c7419d337860ca32cc7a5fee47d1434433c6f0d4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S006512810500022X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15950052$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oruç, Semra</creatorcontrib><creatorcontrib>Vatansever, H. Seda</creatorcontrib><creatorcontrib>Karaer, Öznur</creatorcontrib><creatorcontrib>Eskicioğlu, Fatma</creatorcontrib><creatorcontrib>Narlıkuyu, Burcu</creatorcontrib><title>Changes in distribution patterns of integrins in endometrium in copper T380 intrauterine device users</title><title>Acta histochemica</title><addtitle>Acta Histochem</addtitle><description>Intrauterine contraception is the most cost-effective reversible method of contraception today, but its mechanism of action is not well understood. Our objective was to investigate immunohistochemical distribution patterns of
αv,
α3,
β1 integrins in women using a copper T380 intrauterine device (IUD) for different periods of time to obtain insight into the role of integrins in intrauterine contraception. Endometrial biopsies were obtained from patients using T Cu380A IUD in follicular and luteal phases and in menopausal women grouped according to the period of time of IUD use (group 1: <3 year, and group 2: ⩾3 years). Each group consisted of 10 patients, with a total number of 60 patients. Labelling intensity of all integrins, except for
β1 which increased in the follicular phase, were decreased in women who used IUD for ⩾3 years when compared with group 1 in the follicular and luteal phases and in the menopause. We conclude that long-term use of IUD affects integrin expression in endometrium not only in follicular and luteal phases of premenopausal women but also in postmenopausal women. Copper IUD can inhibit binding of integrins to the extracellular matrix and it may cause inhibition of the implantation stage, which is crucial for pregnancy.</description><subject>Contraception</subject><subject>Endometrium</subject><subject>Endometrium - cytology</subject><subject>Endometrium - metabolism</subject><subject>Female</subject><subject>Follicular Phase - metabolism</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Implantation</subject><subject>Integrin alpha3 - metabolism</subject><subject>Integrin alphaV - metabolism</subject><subject>Integrin beta1 - metabolism</subject><subject>Integrins</subject><subject>Intrauterine Devices, Copper</subject><subject>IUD</subject><subject>Luteal Phase - metabolism</subject><subject>Menopause - metabolism</subject><issn>0065-1281</issn><issn>1618-0372</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9r3DAQxUVISLZJvkEIPuVmd8ayZftSKEv6BwK9JGehlUYbLWvZleRAvn213YXemtMwzO-9gfcYu0OoEFB83lVKp1cXqxqgrQArADxjKxTYl8C7-pytAERbYt3jFfsU4w4ABuD1JbvCdmizql4xWr8qv6VYOF8YF1NwmyW5yRezSomCj8Vk8y3RNjj_lyJvppEyuIyHVU_zTKF45j0cuKCWLHOeCkNvTlOxRArxhl1YtY90e5rX7OXb4_P6R_n06_vP9denUvMBU6mgI2MBOmUHq2zPhWi06HXX4GA473oBWvFa6061lqjpDDa8aTjXwoJpDL9mD0ffOUy_F4pJji5q2u-Vp2mJUnQDZhf8EOR13QIXQwabI6jDFGMgK-fgRhXeJYI89CB38tiDPPQgAWXuIcvuT_7LZiTzT3QKPgNfjgDlON4cBRm1I6_JuEA6STO5_3_4AwI9nB8</recordid><startdate>20050101</startdate><enddate>20050101</enddate><creator>Oruç, Semra</creator><creator>Vatansever, H. 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Seda ; Karaer, Öznur ; Eskicioğlu, Fatma ; Narlıkuyu, Burcu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-a07edf007af9faf83664c68c7419d337860ca32cc7a5fee47d1434433c6f0d4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Contraception</topic><topic>Endometrium</topic><topic>Endometrium - cytology</topic><topic>Endometrium - metabolism</topic><topic>Female</topic><topic>Follicular Phase - metabolism</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Implantation</topic><topic>Integrin alpha3 - metabolism</topic><topic>Integrin alphaV - metabolism</topic><topic>Integrin beta1 - metabolism</topic><topic>Integrins</topic><topic>Intrauterine Devices, Copper</topic><topic>IUD</topic><topic>Luteal Phase - metabolism</topic><topic>Menopause - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oruç, Semra</creatorcontrib><creatorcontrib>Vatansever, H. Seda</creatorcontrib><creatorcontrib>Karaer, Öznur</creatorcontrib><creatorcontrib>Eskicioğlu, Fatma</creatorcontrib><creatorcontrib>Narlıkuyu, Burcu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Acta histochemica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oruç, Semra</au><au>Vatansever, H. Seda</au><au>Karaer, Öznur</au><au>Eskicioğlu, Fatma</au><au>Narlıkuyu, Burcu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in distribution patterns of integrins in endometrium in copper T380 intrauterine device users</atitle><jtitle>Acta histochemica</jtitle><addtitle>Acta Histochem</addtitle><date>2005-01-01</date><risdate>2005</risdate><volume>107</volume><issue>2</issue><spage>95</spage><epage>103</epage><pages>95-103</pages><issn>0065-1281</issn><eissn>1618-0372</eissn><abstract>Intrauterine contraception is the most cost-effective reversible method of contraception today, but its mechanism of action is not well understood. Our objective was to investigate immunohistochemical distribution patterns of
αv,
α3,
β1 integrins in women using a copper T380 intrauterine device (IUD) for different periods of time to obtain insight into the role of integrins in intrauterine contraception. Endometrial biopsies were obtained from patients using T Cu380A IUD in follicular and luteal phases and in menopausal women grouped according to the period of time of IUD use (group 1: <3 year, and group 2: ⩾3 years). Each group consisted of 10 patients, with a total number of 60 patients. Labelling intensity of all integrins, except for
β1 which increased in the follicular phase, were decreased in women who used IUD for ⩾3 years when compared with group 1 in the follicular and luteal phases and in the menopause. We conclude that long-term use of IUD affects integrin expression in endometrium not only in follicular and luteal phases of premenopausal women but also in postmenopausal women. Copper IUD can inhibit binding of integrins to the extracellular matrix and it may cause inhibition of the implantation stage, which is crucial for pregnancy.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>15950052</pmid><doi>10.1016/j.acthis.2005.01.001</doi><tpages>9</tpages></addata></record> |
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| subjects | Contraception Endometrium Endometrium - cytology Endometrium - metabolism Female Follicular Phase - metabolism Humans Immunohistochemistry Implantation Integrin alpha3 - metabolism Integrin alphaV - metabolism Integrin beta1 - metabolism Integrins Intrauterine Devices, Copper IUD Luteal Phase - metabolism Menopause - metabolism |
| title | Changes in distribution patterns of integrins in endometrium in copper T380 intrauterine device users |
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