Using Nonnatural Amino Acids to Control Metal-Coordination Number in Three-Stranded Coiled Coils

It isn't natural: TRI peptides can selectively control the coordination number of a metal center by changing only one of the amino acids in the primary sequence. Replacement of the cysteine residue with penicillamine leads to a three‐coordinate complex CdIIS3, whereas substitution of alanine fo...

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Veröffentlicht in:	Angewandte Chemie International Edition 2006-04, Vol.45 (18), p.2864-2868
Hauptverfasser:	Lee, Kyung-Hoon, Cabello, Chris, Hemmingsen, Lars, Marsh, E. Neil G., Pecoraro, Vincent L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence amino acids Amino Acids - chemistry Biological Products - chemistry cadmium Catalysis coordination modes Magnetic Resonance Spectroscopy metalloproteins Metals - chemistry Models, Molecular Molecular Sequence Data peptides Protein Structure, Tertiary
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	It isn't natural: TRI peptides can selectively control the coordination number of a metal center by changing only one of the amino acids in the primary sequence. Replacement of the cysteine residue with penicillamine leads to a three‐coordinate complex CdIIS3, whereas substitution of alanine for leucine gives four‐coordinate CdS3O (see scheme).
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200504548