Impact of total and central obesity on vascular mortality in patients undergoing coronary angiography

OBJECTIVE: To prospectively investigate the impact of total and central obesity on vascular mortality in patients undergoing coronary angiography. DESIGN: Prospective cohort study; mean follow-up 2.2 y. SUBJECTS: Men ( n =513) and women ( n =243) undergoing coronary angiography for the evaluation of coronary artery disease. MEASUREMENTS: Body mass index (BMI) was used as a measure of total obesity; waist-to-hip ratio (WHR) and waist circumference (WCf) as measures of central obesity. The primary study end point was vascular mortality; secondary study end points were total mortality, major coronary events, and cumulative vascular events. RESULTS: For both genders, BMI, WHR, and WCf correlated significantly with fasting plasma glucose, with HOMA insulin resistance, with triglycerides, and inversely with HDL cholesterol ( P