DNA Methyl Transferase Inhibiting Halogenated Monoterpenes from the Madagascar Red Marine Alga Portieria hornemannii

Three new halogenated monoterpenes, 2, 3, and 4, along with the known compounds halomon (1) and two analogues, 5 and 6, were isolated from the Madagascar red marine alga Portieria hornemannii. The structures of all three new compounds were determined by NMR spectroscopy in combination with mass spec...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2006-04, Vol.69 (4), p.576-579
Hauptverfasser:	Andrianasolo, E.H, France, D, Cornell-Kennon, S, Gerwick, W.H
Format:	Artikel
Sprache:	eng
Schlagworte:	algae and seaweeds Biological and medical sciences chemical structure DNA methyltransferase DNA Modification Methylases - antagonists & inhibitors enzyme inhibition Enzyme Inhibitors - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology General pharmacology halomon Hydrocarbons, Halogenated - chemistry Hydrocarbons, Halogenated - isolation & purification Hydrocarbons, Halogenated - pharmacology Madagascar Medical sciences methyltransferases Molecular Structure Monoterpenes - chemistry Monoterpenes - isolation & purification Monoterpenes - pharmacology monoterpenoids Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Portieria hornemannii Rhizophyllidaceae Rhodophyta - chemistry spectral analysis stereochemistry
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Beschreibung
Zusammenfassung:	Three new halogenated monoterpenes, 2, 3, and 4, along with the known compounds halomon (1) and two analogues, 5 and 6, were isolated from the Madagascar red marine alga Portieria hornemannii. The structures of all three new compounds were determined by NMR spectroscopy in combination with mass spectrometric data analysis. Two of these monoterpenes (1 and 2) were low micromolar inhibitors of DNA methyl transferase-1.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np0503956