Genomic Heterogeneity in Klebsiella pneumoniae Strains Is Associated with Primary Pyogenic Liver Abscess and Metastatic Infection

BackgroundPrimary pyogenic liver abscess (PLA) with septic complication by Klebsiella pneumoniae is an emerging infectious disease Methods and resultsUsing DNA microarray hybridization, we identified a 20-kb chromosomal region that contained 15 open-reading frames (ORFs), including an iron-uptake sy...

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Veröffentlicht in:	The Journal of infectious diseases 2005-07, Vol.192 (1), p.117-128
Hauptverfasser:	Ma, Li-Chen, Fang, Chi-Tai, Lee, Cha-Ze, Shun, Chia-Tung, Wang, Jin-Town
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Biological and medical sciences Chromosome Mapping Endophthalmitis Endophthalmitis - microbiology Fundamental and applied biological sciences. Psychology Genetic Variation Genome, Bacterial Genomes Genomics Humans Infections Infectious diseases Klebsiella Infections - microbiology Klebsiella pneumoniae Klebsiella pneumoniae - genetics Klebsiella pneumoniae - pathogenicity Liver abscess Liver Abscess, Pyogenic - microbiology Medical sciences Meningitis, Bacterial - microbiology Mice Mice, Inbred BALB C Microarray Analysis Microbiology Miscellaneous Open reading frames Operator regions Plasmids Polymerase chain reaction Sepsis - microbiology Tumors Virulence
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Zusammenfassung:	BackgroundPrimary pyogenic liver abscess (PLA) with septic complication by Klebsiella pneumoniae is an emerging infectious disease Methods and resultsUsing DNA microarray hybridization, we identified a 20-kb chromosomal region that contained 15 open-reading frames (ORFs), including an iron-uptake system (kfu) a phosphoenolpyruvate sugar phosphotransferase system (PTS), and 6 unknown ORFs. The region was more prevalent among tissue-invasive strains (35/46) than among noninvasive strains (19/98) (P
ISSN:	0022-1899 1537-6613
DOI:	10.1086/430619