Sesquiterpene Lactones from Inula britannica and Their Cytotoxic and Apoptotic Effects on Human Cancer Cell Lines

Three new sesquiterpenes (1-3), together with four known sesquiterpene lactones, were isolated from the flowers of Inula britannica var. chinensis. Structures were established on the basis of high-field 1D and 2D NMR methods supported by HRMS. All sesquiterpene lactones were tested for cytotoxicity...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2006-04, Vol.69 (4), p.531-535
Hauptverfasser:	BAI, Naisheng, LAI, Ching-Shu, HE, Kan, ZHOU, Zhu, ZHANG, Li, QUAN, Zheng, ZHU, Nanqun, ZHENG, Qun Yi, PAN, Min-Hsiung, HO, Chi-Tang
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Cell Line, Tumor Drug Screening Assays, Antitumor Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - isolation & purification Drugs, Chinese Herbal - pharmacology Flowers - chemistry General aspects General pharmacology Humans Inula - chemistry Lactones - chemistry Lactones - isolation & purification Lactones - pharmacology Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology
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Zusammenfassung:	Three new sesquiterpenes (1-3), together with four known sesquiterpene lactones, were isolated from the flowers of Inula britannica var. chinensis. Structures were established on the basis of high-field 1D and 2D NMR methods supported by HRMS. All sesquiterpene lactones were tested for cytotoxicity as well as apoptotic ratio in human COLO 205, HT 29, HL-60, and AGS cancer cells. Compounds 3 and 4, two alpha-methylene gamma-lactone-bearing sesquiterpenes, were modestly active in these assays.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np050437q