Significant Reduction in Inflammatory Response in the Macaque Model of Chlamydial Pelvic Inflammatory Disease with Azithromycin Treatment

We inoculated 45 female macaques in the cervix with Chlamydia trachomatis once weekly for 5 weeks and randomly assigned them to treatment with doxycycline (n=12), azithromycin (n=12), or placebo (n=21). At hysterectomy, cervical cultures remained positive in 12 of 21 placebo-treated monkeys, versus...

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Veröffentlicht in:	The Journal of infectious diseases 2005-07, Vol.192 (1), p.129-135
Hauptverfasser:	Patton, Dorothy L., Sweeney, Yvonne T. Cosgrove, Stamm, Walter E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - therapeutic use Azithromycin - therapeutic use Bacteria Bacterial diseases Bacterial diseases of the genital system Bacteriology Biological and medical sciences Cervix uteri Chlamydia Infections - drug therapy Chlamydia Infections - physiopathology Chlamydia trachomatis Female Fibrosis Fundamental and applied biological sciences. Psychology Human bacterial diseases Hysterectomy Infections Infectious diseases Macaca Macaca nemestrina Medical sciences Microbiology Miscellaneous Patient assessment Pelvic inflammatory disease Pelvic Inflammatory Disease - drug therapy Pelvic Inflammatory Disease - microbiology Pelvic Inflammatory Disease - physiopathology Placebos Plasma cells Reproductive tract infections
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Zusammenfassung:	We inoculated 45 female macaques in the cervix with Chlamydia trachomatis once weekly for 5 weeks and randomly assigned them to treatment with doxycycline (n=12), azithromycin (n=12), or placebo (n=21). At hysterectomy, cervical cultures remained positive in 12 of 21 placebo-treated monkeys, versus 0 of 12 doxycycline- or azithromycin-treated monkeys (P
ISSN:	0022-1899 1537-6613
DOI:	10.1086/431365