Diabetic Nephropathy in Pregnancy: Suboptimal Hypertensive Control Associated With Preterm Delivery
Nephropathy complicates 5% to 10% of pregnancies in women with diabetes and is associated with adverse outcomes. Given the importance of blood pressure (BP) control in reducing cardiovascular and renal complications outside of pregnancy, we hypothesized that poorly controlled hypertension in early p...
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creator | Carr, Darcy B. Koontz, Gretchen L. Gardella, Carolyn Holing, Emily V. Brateng, Debra A. Brown, Zane A. Easterling, Thomas R. |
description | Nephropathy complicates 5% to 10% of pregnancies in women with diabetes and is associated with adverse outcomes. Given the importance of blood pressure (BP) control in reducing cardiovascular and renal complications outside of pregnancy, we hypothesized that poorly controlled hypertension in early pregnancy among women with diabetic nephropathy would be associated with adverse outcomes.
To examine the impact of hypertensive control in early pregnancy on perinatal outcomes, we performed a retrospective cohort study of pregnancies complicated by diabetic nephropathy with “Above Target” mean arterial pressure (≥100 mm Hg;
N = 21) and “Below Target” mean arterial pressure ( |
doi_str_mv | 10.1016/j.amjhyper.2005.12.010 |
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To examine the impact of hypertensive control in early pregnancy on perinatal outcomes, we performed a retrospective cohort study of pregnancies complicated by diabetic nephropathy with “Above Target” mean arterial pressure (≥100 mm Hg;
N = 21) and “Below Target” mean arterial pressure (<100 mm Hg;
N = 22), which approximates the American Diabetes Association and the Seventh Report of the Joint National Committee recommended target of 130/80 mm Hg, measured at <20 weeks’ gestation.
There were no differences in maternal age (mean ± SEM: 27.2 ± 1.2
v 29.5 ± 1.0 years), duration of diabetes (median, range: 17.5, 13 to 24
v 16, 1 to 25 years), or glucose control (glycosylated hemoglobin [HbA
1c] 8.0% ± 0.3%
v 8.1% ± 0.4%) between the Above and Below Target groups. The Above Target group had more proteinuria (4.69 ± 1.08
v 1.65 ± 0.43 g/24 h;
P = .007) and higher serum creatinine levels (1.23 ± 0.17
v 0.85 ± 0.06 mg/dL;
P = .02). The Above Target group was more likely to deliver at <32 weeks’ gestation (38.1%
v 4.6%;
P = .007). The increased risk of preterm delivery remained significant after adjusting for duration of diabetes and glucose control.
Suboptimal control of hypertension in early pregnancy in women with diabetic nephropathy is associated with a significant risk of preterm delivery. Improved preconceptional control of hypertension may reduce adverse perinatal outcomes in women with diabetic nephropathy.</description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1879-1905</identifier><identifier>EISSN: 1941-7225</identifier><identifier>DOI: 10.1016/j.amjhyper.2005.12.010</identifier><identifier>PMID: 16647626</identifier><identifier>CODEN: AJHYE6</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Arterial hypertension. Arterial hypotension ; Associated diseases and complications ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Glucose - metabolism ; Blood Pressure - physiology ; Cardiac Output - physiology ; Cardiology. Vascular system ; Diabetes. Impaired glucose tolerance ; Diabetic Nephropathies - blood ; Diabetic Nephropathies - complications ; Diabetic Nephropathies - physiopathology ; Diabetic nephropathy ; Diseases of mother, fetus and pregnancy ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Female ; Follow-Up Studies ; Gynecology. Andrology. Obstetrics ; Humans ; hypertension ; Hypertension - etiology ; Hypertension - physiopathology ; Hypertension - prevention & control ; Incidence ; Infant, Newborn ; Medical sciences ; Obstetric Labor, Premature - epidemiology ; Obstetric Labor, Premature - etiology ; Pregnancy ; Pregnancy Complications ; Pregnancy. Fetus. Placenta ; preterm delivery ; Prognosis ; Retrospective Studies</subject><ispartof>American journal of hypertension, 2006-05, Vol.19 (5), p.513-519</ispartof><rights>2006 American Journal of Hypertension, Ltd.</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Nature Publishing Group May 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-9c6fbcbc21cf70d9de6c89280b8dde9a34551407cfc07d5202998eafc3307e893</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17768250$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16647626$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carr, Darcy B.</creatorcontrib><creatorcontrib>Koontz, Gretchen L.</creatorcontrib><creatorcontrib>Gardella, Carolyn</creatorcontrib><creatorcontrib>Holing, Emily V.</creatorcontrib><creatorcontrib>Brateng, Debra A.</creatorcontrib><creatorcontrib>Brown, Zane A.</creatorcontrib><creatorcontrib>Easterling, Thomas R.</creatorcontrib><title>Diabetic Nephropathy in Pregnancy: Suboptimal Hypertensive Control Associated With Preterm Delivery</title><title>American journal of hypertension</title><addtitle>AJH</addtitle><description>Nephropathy complicates 5% to 10% of pregnancies in women with diabetes and is associated with adverse outcomes. Given the importance of blood pressure (BP) control in reducing cardiovascular and renal complications outside of pregnancy, we hypothesized that poorly controlled hypertension in early pregnancy among women with diabetic nephropathy would be associated with adverse outcomes.
To examine the impact of hypertensive control in early pregnancy on perinatal outcomes, we performed a retrospective cohort study of pregnancies complicated by diabetic nephropathy with “Above Target” mean arterial pressure (≥100 mm Hg;
N = 21) and “Below Target” mean arterial pressure (<100 mm Hg;
N = 22), which approximates the American Diabetes Association and the Seventh Report of the Joint National Committee recommended target of 130/80 mm Hg, measured at <20 weeks’ gestation.
There were no differences in maternal age (mean ± SEM: 27.2 ± 1.2
v 29.5 ± 1.0 years), duration of diabetes (median, range: 17.5, 13 to 24
v 16, 1 to 25 years), or glucose control (glycosylated hemoglobin [HbA
1c] 8.0% ± 0.3%
v 8.1% ± 0.4%) between the Above and Below Target groups. The Above Target group had more proteinuria (4.69 ± 1.08
v 1.65 ± 0.43 g/24 h;
P = .007) and higher serum creatinine levels (1.23 ± 0.17
v 0.85 ± 0.06 mg/dL;
P = .02). The Above Target group was more likely to deliver at <32 weeks’ gestation (38.1%
v 4.6%;
P = .007). The increased risk of preterm delivery remained significant after adjusting for duration of diabetes and glucose control.
Suboptimal control of hypertension in early pregnancy in women with diabetic nephropathy is associated with a significant risk of preterm delivery. Improved preconceptional control of hypertension may reduce adverse perinatal outcomes in women with diabetic nephropathy.</description><subject>Adult</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Associated diseases and complications</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Glucose - metabolism</subject><subject>Blood Pressure - physiology</subject><subject>Cardiac Output - physiology</subject><subject>Cardiology. Vascular system</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diabetic Nephropathies - blood</subject><subject>Diabetic Nephropathies - complications</subject><subject>Diabetic Nephropathies - physiopathology</subject><subject>Diabetic nephropathy</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>hypertension</subject><subject>Hypertension - etiology</subject><subject>Hypertension - physiopathology</subject><subject>Hypertension - prevention & control</subject><subject>Incidence</subject><subject>Infant, Newborn</subject><subject>Medical sciences</subject><subject>Obstetric Labor, Premature - epidemiology</subject><subject>Obstetric Labor, Premature - etiology</subject><subject>Pregnancy</subject><subject>Pregnancy Complications</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>preterm delivery</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><issn>0895-7061</issn><issn>1879-1905</issn><issn>1941-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqF0ctu1DAUBuAIgei08AolEoJdgu3EN1ZU05YBDReJq7qxHOeEcZpJgu1UzNvjaAZGYsPKm-9cfP4kOccoxwizF22ut-1mN4LLCUI0xyRHGN1LFlhwmWGJ6P1kgYSkGUcMnySn3rcIoZIx_DA5wYyVnBG2SMyl1RUEa9L3MG7cMOqw2aW2Tz86-NHr3uxepp-mahiD3eouXc0TA_Te3kG6HPrghi698H4wVgeo0282bObSAG6bXkIXmds9Sh40uvPw-PCeJV-urz4vV9n6w-s3y4t1ZmhRhkwa1lSmMgSbhqNa1sCMkESgStQ1SF2UlOIScdMYxGtKEJFSgG5MUSAOQhZnyfN939ENPyfwQW2tN9B1uodh8opxiQkmRYRP_4HtMLk-7qYwIpSXjAsRFdsr4wbvHTRqdPEIbheRmkNQrfoTgppDUJioGEIsPD-0n6ot1Meyw9UjeHYA2hvdNS7e2fqj45wJQudGT_au12Fy8BfodhPnMUmjyPbC-gC_jsDdxt8WnKrV9xtVrunN13fXQr2N_tXeQ8zhzsbFvbHQG6itAxNUPdj__e43PkPDpA</recordid><startdate>20060501</startdate><enddate>20060501</enddate><creator>Carr, Darcy B.</creator><creator>Koontz, Gretchen L.</creator><creator>Gardella, Carolyn</creator><creator>Holing, Emily V.</creator><creator>Brateng, Debra A.</creator><creator>Brown, Zane A.</creator><creator>Easterling, Thomas R.</creator><general>Elsevier Inc</general><general>Oxford University Press</general><general>Elsevier Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20060501</creationdate><title>Diabetic Nephropathy in Pregnancy: Suboptimal Hypertensive Control Associated With Preterm Delivery</title><author>Carr, Darcy B. ; Koontz, Gretchen L. ; Gardella, Carolyn ; Holing, Emily V. ; Brateng, Debra A. ; Brown, Zane A. ; Easterling, Thomas R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-9c6fbcbc21cf70d9de6c89280b8dde9a34551407cfc07d5202998eafc3307e893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Associated diseases and complications</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Glucose - metabolism</topic><topic>Blood Pressure - physiology</topic><topic>Cardiac Output - physiology</topic><topic>Cardiology. Vascular system</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diabetic Nephropathies - blood</topic><topic>Diabetic Nephropathies - complications</topic><topic>Diabetic Nephropathies - physiopathology</topic><topic>Diabetic nephropathy</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>hypertension</topic><topic>Hypertension - etiology</topic><topic>Hypertension - physiopathology</topic><topic>Hypertension - prevention & control</topic><topic>Incidence</topic><topic>Infant, Newborn</topic><topic>Medical sciences</topic><topic>Obstetric Labor, Premature - epidemiology</topic><topic>Obstetric Labor, Premature - etiology</topic><topic>Pregnancy</topic><topic>Pregnancy Complications</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>preterm delivery</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carr, Darcy B.</creatorcontrib><creatorcontrib>Koontz, Gretchen L.</creatorcontrib><creatorcontrib>Gardella, Carolyn</creatorcontrib><creatorcontrib>Holing, Emily V.</creatorcontrib><creatorcontrib>Brateng, Debra A.</creatorcontrib><creatorcontrib>Brown, Zane A.</creatorcontrib><creatorcontrib>Easterling, Thomas R.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carr, Darcy B.</au><au>Koontz, Gretchen L.</au><au>Gardella, Carolyn</au><au>Holing, Emily V.</au><au>Brateng, Debra A.</au><au>Brown, Zane A.</au><au>Easterling, Thomas R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diabetic Nephropathy in Pregnancy: Suboptimal Hypertensive Control Associated With Preterm Delivery</atitle><jtitle>American journal of hypertension</jtitle><addtitle>AJH</addtitle><date>2006-05-01</date><risdate>2006</risdate><volume>19</volume><issue>5</issue><spage>513</spage><epage>519</epage><pages>513-519</pages><issn>0895-7061</issn><eissn>1879-1905</eissn><eissn>1941-7225</eissn><coden>AJHYE6</coden><abstract>Nephropathy complicates 5% to 10% of pregnancies in women with diabetes and is associated with adverse outcomes. Given the importance of blood pressure (BP) control in reducing cardiovascular and renal complications outside of pregnancy, we hypothesized that poorly controlled hypertension in early pregnancy among women with diabetic nephropathy would be associated with adverse outcomes.
To examine the impact of hypertensive control in early pregnancy on perinatal outcomes, we performed a retrospective cohort study of pregnancies complicated by diabetic nephropathy with “Above Target” mean arterial pressure (≥100 mm Hg;
N = 21) and “Below Target” mean arterial pressure (<100 mm Hg;
N = 22), which approximates the American Diabetes Association and the Seventh Report of the Joint National Committee recommended target of 130/80 mm Hg, measured at <20 weeks’ gestation.
There were no differences in maternal age (mean ± SEM: 27.2 ± 1.2
v 29.5 ± 1.0 years), duration of diabetes (median, range: 17.5, 13 to 24
v 16, 1 to 25 years), or glucose control (glycosylated hemoglobin [HbA
1c] 8.0% ± 0.3%
v 8.1% ± 0.4%) between the Above and Below Target groups. The Above Target group had more proteinuria (4.69 ± 1.08
v 1.65 ± 0.43 g/24 h;
P = .007) and higher serum creatinine levels (1.23 ± 0.17
v 0.85 ± 0.06 mg/dL;
P = .02). The Above Target group was more likely to deliver at <32 weeks’ gestation (38.1%
v 4.6%;
P = .007). The increased risk of preterm delivery remained significant after adjusting for duration of diabetes and glucose control.
Suboptimal control of hypertension in early pregnancy in women with diabetic nephropathy is associated with a significant risk of preterm delivery. Improved preconceptional control of hypertension may reduce adverse perinatal outcomes in women with diabetic nephropathy.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16647626</pmid><doi>10.1016/j.amjhyper.2005.12.010</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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source | Oxford University Press Journals All Titles (1996-Current); MEDLINE |
subjects | Adult Arterial hypertension. Arterial hypotension Associated diseases and complications Biological and medical sciences Blood and lymphatic vessels Blood Glucose - metabolism Blood Pressure - physiology Cardiac Output - physiology Cardiology. Vascular system Diabetes. Impaired glucose tolerance Diabetic Nephropathies - blood Diabetic Nephropathies - complications Diabetic Nephropathies - physiopathology Diabetic nephropathy Diseases of mother, fetus and pregnancy Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Follow-Up Studies Gynecology. Andrology. Obstetrics Humans hypertension Hypertension - etiology Hypertension - physiopathology Hypertension - prevention & control Incidence Infant, Newborn Medical sciences Obstetric Labor, Premature - epidemiology Obstetric Labor, Premature - etiology Pregnancy Pregnancy Complications Pregnancy. Fetus. Placenta preterm delivery Prognosis Retrospective Studies |
title | Diabetic Nephropathy in Pregnancy: Suboptimal Hypertensive Control Associated With Preterm Delivery |
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