Procyanidin Fractions from Pine (Pinus pinaster) Bark: Radical Scavenging Power in Solution, Antioxidant Activity in Emulsion, and Antiproliferative Effect in Melanoma Cells
Pine (Pinus pinaster) bark is a rich source of procyanidin oligomers. From a total polyphenolic extract, we have generated fractions of different procyanidin composition. The mixtures, devoid of gallate esters, were active as free radical scavengers against ABTS•+, DPPH, and HNTTM. Pine bark fractio...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2005-06, Vol.53 (12), p.4728-4735 |
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| container_title | Journal of agricultural and food chemistry |
| container_volume | 53 |
| creator | Touriño, Sonia Selga, Ariadna Jiménez, Aurora Juliá, Lluís Lozano, Carles Lizárraga, Daneida Cascante, Marta Torres, Josep Lluís |
| description | Pine (Pinus pinaster) bark is a rich source of procyanidin oligomers. From a total polyphenolic extract, we have generated fractions of different procyanidin composition. The mixtures, devoid of gallate esters, were active as free radical scavengers against ABTS•+, DPPH, and HNTTM. Pine bark fractions were tested for antioxidant activity in solution (hydrogen donation and electron transfer) and emulsion (inhibition of lipid peroxidation) and compared with their galloylated counterparts from grape origin. While galloylation clearly influenced the free radical scavenging efficiency in solution, it did not seem to play a determinant role in protection against lipid peroxidation in emulsion. The fractions were very mild inhibitors of cell proliferation. Because gallate esters appear to interfere with crucial cell functions, gallate free pine procyanidins may be the innocuous chemopreventative agents of choice for many applications in food and skin protection. Keywords: Pinus pinaster; polyphenols; procyanidins; catechins; antioxidants; free radical scavenging activity; emulsions; cell proliferation |
| doi_str_mv | 10.1021/jf050262q |
| format | Article |
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From a total polyphenolic extract, we have generated fractions of different procyanidin composition. The mixtures, devoid of gallate esters, were active as free radical scavengers against ABTS•+, DPPH, and HNTTM. Pine bark fractions were tested for antioxidant activity in solution (hydrogen donation and electron transfer) and emulsion (inhibition of lipid peroxidation) and compared with their galloylated counterparts from grape origin. While galloylation clearly influenced the free radical scavenging efficiency in solution, it did not seem to play a determinant role in protection against lipid peroxidation in emulsion. The fractions were very mild inhibitors of cell proliferation. Because gallate esters appear to interfere with crucial cell functions, gallate free pine procyanidins may be the innocuous chemopreventative agents of choice for many applications in food and skin protection. Keywords: Pinus pinaster; polyphenols; procyanidins; catechins; antioxidants; free radical scavenging activity; emulsions; cell proliferation</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf050262q</identifier><identifier>PMID: 15941307</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Antioxidants - pharmacology ; Cell Division - drug effects ; Emulsions ; Free Radical Scavengers - pharmacology ; Humans ; Melanoma - pathology ; Pinus - chemistry ; Plant Bark - chemistry ; Proanthocyanidins - analysis ; Proanthocyanidins - pharmacology ; Solutions ; Tumor Cells, Cultured</subject><ispartof>Journal of agricultural and food chemistry, 2005-06, Vol.53 (12), p.4728-4735</ispartof><rights>Copyright © 2005 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a351t-6713c0df84d6a95612a0794e76de70399c057cbed0959f882a2ff226eb3f0a2e3</citedby><cites>FETCH-LOGICAL-a351t-6713c0df84d6a95612a0794e76de70399c057cbed0959f882a2ff226eb3f0a2e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf050262q$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf050262q$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2763,27075,27923,27924,56737,56787</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15941307$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Touriño, Sonia</creatorcontrib><creatorcontrib>Selga, Ariadna</creatorcontrib><creatorcontrib>Jiménez, Aurora</creatorcontrib><creatorcontrib>Juliá, Lluís</creatorcontrib><creatorcontrib>Lozano, Carles</creatorcontrib><creatorcontrib>Lizárraga, Daneida</creatorcontrib><creatorcontrib>Cascante, Marta</creatorcontrib><creatorcontrib>Torres, Josep Lluís</creatorcontrib><title>Procyanidin Fractions from Pine (Pinus pinaster) Bark: Radical Scavenging Power in Solution, Antioxidant Activity in Emulsion, and Antiproliferative Effect in Melanoma Cells</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>Pine (Pinus pinaster) bark is a rich source of procyanidin oligomers. From a total polyphenolic extract, we have generated fractions of different procyanidin composition. The mixtures, devoid of gallate esters, were active as free radical scavengers against ABTS•+, DPPH, and HNTTM. Pine bark fractions were tested for antioxidant activity in solution (hydrogen donation and electron transfer) and emulsion (inhibition of lipid peroxidation) and compared with their galloylated counterparts from grape origin. While galloylation clearly influenced the free radical scavenging efficiency in solution, it did not seem to play a determinant role in protection against lipid peroxidation in emulsion. The fractions were very mild inhibitors of cell proliferation. Because gallate esters appear to interfere with crucial cell functions, gallate free pine procyanidins may be the innocuous chemopreventative agents of choice for many applications in food and skin protection. Keywords: Pinus pinaster; polyphenols; procyanidins; catechins; antioxidants; free radical scavenging activity; emulsions; cell proliferation</description><subject>Antioxidants - pharmacology</subject><subject>Cell Division - drug effects</subject><subject>Emulsions</subject><subject>Free Radical Scavengers - pharmacology</subject><subject>Humans</subject><subject>Melanoma - pathology</subject><subject>Pinus - chemistry</subject><subject>Plant Bark - chemistry</subject><subject>Proanthocyanidins - analysis</subject><subject>Proanthocyanidins - pharmacology</subject><subject>Solutions</subject><subject>Tumor Cells, Cultured</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0cFuEzEQBmALgWhaOPACyBcQlViwvfF6zS1ECSAVETXhbE28duWwa6f2btvcuPI2PBNPgtNE5cLFc_Cnf0YzCL2g5B0ljL7fWMIJq9j1IzSinJGCU1o_RiOSP4uaV_QEnaa0IYTUXJCn6IRyOaYlESP0exGD3oF3jfN4HkH3LviEbQwdXjhv8Jv8DglvnYfUm3iOP0L88eHPz1_4EhqnocVLDTfGXzl_hRfh1kSck5ahHfZJb_HE53rnGvA9nuT0G9fv9mLWDW26F-Cbe7WNoXXWRMjI4Jm1Rvd7-dW04EMHeGraNj1DTyy0yTw_1jP0fT5bTT8XF98-fZlOLgooOe2LStBSk8bW46YCmVfAgAg5NqJqjCCllJpwodemIZJLW9cMmLWMVWZdWgLMlGfo9SE3j3U9mNSrziWdJwBvwpBUJSSRVUkyPD9AHUNK0Vi1ja6DuFOUqP151MN5sn15DB3WnWn-yeM9MigOwOVl3z3855XnhqXgarVYqqmYr1gtL9Uy-1cHDzqpTRiizzv5T-O_U-qo6A</recordid><startdate>20050615</startdate><enddate>20050615</enddate><creator>Touriño, Sonia</creator><creator>Selga, Ariadna</creator><creator>Jiménez, Aurora</creator><creator>Juliá, Lluís</creator><creator>Lozano, Carles</creator><creator>Lizárraga, Daneida</creator><creator>Cascante, Marta</creator><creator>Torres, Josep Lluís</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050615</creationdate><title>Procyanidin Fractions from Pine (Pinus pinaster) Bark: Radical Scavenging Power in Solution, Antioxidant Activity in Emulsion, and Antiproliferative Effect in Melanoma Cells</title><author>Touriño, Sonia ; Selga, Ariadna ; Jiménez, Aurora ; Juliá, Lluís ; Lozano, Carles ; Lizárraga, Daneida ; Cascante, Marta ; Torres, Josep Lluís</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a351t-6713c0df84d6a95612a0794e76de70399c057cbed0959f882a2ff226eb3f0a2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Antioxidants - pharmacology</topic><topic>Cell Division - drug effects</topic><topic>Emulsions</topic><topic>Free Radical Scavengers - pharmacology</topic><topic>Humans</topic><topic>Melanoma - pathology</topic><topic>Pinus - chemistry</topic><topic>Plant Bark - chemistry</topic><topic>Proanthocyanidins - analysis</topic><topic>Proanthocyanidins - pharmacology</topic><topic>Solutions</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Touriño, Sonia</creatorcontrib><creatorcontrib>Selga, Ariadna</creatorcontrib><creatorcontrib>Jiménez, Aurora</creatorcontrib><creatorcontrib>Juliá, Lluís</creatorcontrib><creatorcontrib>Lozano, Carles</creatorcontrib><creatorcontrib>Lizárraga, Daneida</creatorcontrib><creatorcontrib>Cascante, Marta</creatorcontrib><creatorcontrib>Torres, Josep Lluís</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Touriño, Sonia</au><au>Selga, Ariadna</au><au>Jiménez, Aurora</au><au>Juliá, Lluís</au><au>Lozano, Carles</au><au>Lizárraga, Daneida</au><au>Cascante, Marta</au><au>Torres, Josep Lluís</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Procyanidin Fractions from Pine (Pinus pinaster) Bark: Radical Scavenging Power in Solution, Antioxidant Activity in Emulsion, and Antiproliferative Effect in Melanoma Cells</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2005-06-15</date><risdate>2005</risdate><volume>53</volume><issue>12</issue><spage>4728</spage><epage>4735</epage><pages>4728-4735</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><abstract>Pine (Pinus pinaster) bark is a rich source of procyanidin oligomers. From a total polyphenolic extract, we have generated fractions of different procyanidin composition. The mixtures, devoid of gallate esters, were active as free radical scavengers against ABTS•+, DPPH, and HNTTM. Pine bark fractions were tested for antioxidant activity in solution (hydrogen donation and electron transfer) and emulsion (inhibition of lipid peroxidation) and compared with their galloylated counterparts from grape origin. While galloylation clearly influenced the free radical scavenging efficiency in solution, it did not seem to play a determinant role in protection against lipid peroxidation in emulsion. The fractions were very mild inhibitors of cell proliferation. 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| subjects | Antioxidants - pharmacology Cell Division - drug effects Emulsions Free Radical Scavengers - pharmacology Humans Melanoma - pathology Pinus - chemistry Plant Bark - chemistry Proanthocyanidins - analysis Proanthocyanidins - pharmacology Solutions Tumor Cells, Cultured |
| title | Procyanidin Fractions from Pine (Pinus pinaster) Bark: Radical Scavenging Power in Solution, Antioxidant Activity in Emulsion, and Antiproliferative Effect in Melanoma Cells |
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