Hepatitis B virus genotypes and G1896A precore mutation in 486 Spanish patients with acute and chronic HBV infection

This study aims to determine the prevalence of hepatitis B virus (HBV) genotypes (A–F) and their association with the G1896A precore mutation in 486 patients positive for HBV surface antigen. Genotypes were determined by RFLP and precore mutation by real‐time PCR. Genotypes D (48.1%) and A (39.5%) w...

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Veröffentlicht in:	Journal of viral hepatitis 2006-05, Vol.13 (5), p.343-350
Hauptverfasser:	Rodriguez-Frias, F., Jardi, R., Buti, M., Schaper, M., Hermosilla, E., Valdes, A., Allende, H., Martell, M., Esteban, R., Guardia, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	acute HBV infection Adolescent Adult Aged Alanine Transaminase - blood chronic hepatitis B Cohort Studies DNA, Viral - chemistry DNA, Viral - genetics Female Genotype HBV genotypes HBV-DNA Hepatitis B e Antigens - blood Hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - immunology Hepatitis B, Chronic - blood Hepatitis B, Chronic - epidemiology Hepatitis B, Chronic - pathology Hepatitis B, Chronic - virology Histocytochemistry Humans Liver Cirrhosis - pathology Liver Cirrhosis - virology Male Middle Aged Multivariate Analysis Polymerase Chain Reaction Polymorphism, Single Nucleotide precore mutant Retrospective Studies Spain - epidemiology Statistics, Nonparametric viral coinfection
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Zusammenfassung:	This study aims to determine the prevalence of hepatitis B virus (HBV) genotypes (A–F) and their association with the G1896A precore mutation in 486 patients positive for HBV surface antigen. Genotypes were determined by RFLP and precore mutation by real‐time PCR. Genotypes D (48.1%) and A (39.5%) were the most common, followed by F (4.1%) and B, C and E (
ISSN:	1352-0504 1365-2893
DOI:	10.1111/j.1365-2893.2005.00691.x