The ICAM-1 E469K gene polymorphism is a risk factor for spontaneous cervical artery dissection

The ICAM-1 E469K gene polymorphism is a risk factor for spontaneous cervical artery dissection

In a primary study on proinflammatory genetic profiles in stroke, the authors found the E469K polymorphism of the intercellular adhesion molecule 1 (ICAM-1) highly represented in the subgroup with spontaneous cervical artery dissection (sCAD). They further investigated the same genetic variant in a...

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Veröffentlicht in:Neurology 2006-04, Vol.66 (8), p.1273-1275
Hauptverfasser: LONGONI, M, GROND-GINSBACH, C, GRAU, A. J, GENIUS, J, DEBETTE, S, SCHWANINGER, M, FERRARESE, C, LICHY, C
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Alleles
Amino Acid Substitution - genetics
Biological and medical sciences
Female
Genotype
Glutamic Acid - genetics
Humans
Intercellular Adhesion Molecule-1 - genetics
Intercellular Adhesion Molecule-1 - physiology
Lysine - genetics
Male
Medical sciences
Neurology
Orthopedic surgery
Polymorphism, Genetic
Risk Factors
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Vascular diseases and vascular malformations of the nervous system
Vertebral Artery Dissection - genetics
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Zusammenfassung:In a primary study on proinflammatory genetic profiles in stroke, the authors found the E469K polymorphism of the intercellular adhesion molecule 1 (ICAM-1) highly represented in the subgroup with spontaneous cervical artery dissection (sCAD). They further investigated the same genetic variant in a second group of 65 patients with sCAD. An association between sCAD and EE genotype was confirmed (odds ratio 3.16; p < 0.01), indicating that a proinflammatory predisposition is a risk factor for sCAD.
ISSN:0028-3878
1526-632X
DOI:10.1212/01.wnl.0000208411.01172.0b