Interferon-gamma and neopterin in blood serum of patients with chronic periodontitis after autograft operations

The aim of the study was to compare the serum levels of interferon-gamma (INF-gamma) and neopterin (NPT) in 10 patients with mild form of chronic periodontitis before and after operations. Overall objective of these operations is the elimination of periodontal and osseous pockets. 10 blood donors were included in the control group. The serum levels of INF-gamma and NPT were measured using enzyme immunoassay technique. INF-gamma and neopterin in patients with chronic periodontitis were assessed before and 4 to 6 weeks after the operation. The mean serum INF-gamma in patients with mild form of chronic periodontitis (n=10) was 13,2+/-4,03 pg/mL. The mean serum INF-gamma level in patients with mild form of chronic periodontitis (n=10) after the operations was 10,05+/-3,12 pg/mL. Serum levels of INF-gamma in patients with mild form chronic periodontitis were significantly higher than those in the control group. There was no significant difference in serum levels of INF-gamma in patients with mild form before and after operations. The mean serum level of NPT in the control was 5,3+/-2,39 nmol/L. The mean serum NPT level in patients (n=10) with mild form chronic parodontitis was 14,4+/-10,05 nmol/L. After operations NPT concentration were reduced (6,9+/-3,39 nmol/L). Serum levels of NTP in patients with mild form chronic periodontitis were significantly higher than those in the control group. Significant difference was observed in serum levels of NPT in patients with mild form of chronic periodontitis before and after operations. Obtained data allow specifying the mechanism of positive influence of autograft operations on the pathogenesis of chronic periodontitis.