Identification and localisation of the NR1 sub-unit homologue of the NMDA glutamate receptor in the honeybee brain

The NR1 sub-unit homologue of the NMDA glutamate receptor was characterised in the honeybee. Sequence analysis suggests that the honeybee NMDA receptor may act as a coincidence detector molecule similar to its counterpart in the mammalian nervous system. The localisation of the expression sites at t...

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Veröffentlicht in:	Neuroscience letters 2006-05, Vol.398 (3), p.274-279
Hauptverfasser:	Zannat, Mst. Thangima, Locatelli, Fernando, Rybak, Jürgen, Menzel, Randolf, Leboulle, Gérard
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Apis mellifera Bees - metabolism Brain - metabolism Immunohistochemistry In situ hybridisation In Situ Hybridization Insects Molecular Sequence Data NMDA glutamate receptor Protein Subunits - genetics Protein Subunits - metabolism Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - metabolism RNA, Messenger - metabolism
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Zusammenfassung:	The NR1 sub-unit homologue of the NMDA glutamate receptor was characterised in the honeybee. Sequence analysis suggests that the honeybee NMDA receptor may act as a coincidence detector molecule similar to its counterpart in the mammalian nervous system. The localisation of the expression sites at the mRNA and the protein levels indicates that the receptor is expressed throughout the brain, in neurons and in glial cells.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/j.neulet.2006.01.007