Evaluation of Tumor Cell Dissociation as a Predictive Marker of Lymph Node Metastasis in Submucosal Invasive Colorectal Carcinoma

PURPOSE: METHODS: RESULTS:Tumor cell dissociation was more frequently identified in submucosal invasive colorectal carcinoma cases with lymph node metastasis than in those without lymph node metastasis (P = 0.0001). Decreased membranous expression of E-cadherin occurred more frequently in submucosal...

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Veröffentlicht in:	Diseases of the colon & rectum 2005-05, Vol.48 (5), p.938-945
Hauptverfasser:	Hori, Hiroshige, Fujimori, Takahiro, Fujii, Shigehiko, Ichikawa, Kazuhito, Ohkura, Yasuo, Tomita, Shigeki, Ono, Yuko, Imura, Johji, Kuroda, Yoshikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	beta Catenin Biological and medical sciences Cadherins - metabolism Chi-Square Distribution Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Cytoskeletal Proteins - metabolism Endoscopy, Gastrointestinal Gastroenterology. Liver. Pancreas. Abdomen Humans Immunoenzyme Techniques Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Lymphatic Metastasis Medical sciences Neoplasm Invasiveness Predictive Value of Tests Prognosis Risk Factors Staining and Labeling Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Trans-Activators - metabolism Tumors
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Zusammenfassung:	PURPOSE: METHODS: RESULTS:Tumor cell dissociation was more frequently identified in submucosal invasive colorectal carcinoma cases with lymph node metastasis than in those without lymph node metastasis (P = 0.0001). Decreased membranous expression of E-cadherin occurred more frequently in submucosal invasive colorectal carcinoma cases with lymph node metastasis than in those without lymph node metastasis (P = 0.025). Nuclear expression of beta-catenin tended to be present in submucosal invasive colorectal carcinoma cases with lymph node metastasis (P = 0.063). Decreased membranous expression of E-cadherin occurred more frequently in submucosal invasive colorectal carcinoma cases with tumor cell dissociation than in those without tumor cell dissociation (P = 0.0023). CONCLUSIONS:
ISSN:	0012-3706 1530-0358
DOI:	10.1007/s10350-004-0883-6