Synthesis of Methyl 1-O-(4-Hydroxymethamphetaminyl)-α-D-glucopyranouronate

Synthesis of Methyl 1-O-(4-Hydroxymethamphetaminyl)-α-D-glucopyranouronate

For the purpose of the direct characterization of the intact conjugated form in the urine of a methamphetamine (MA) abuser, 4-hydroxymethamphetamine (4-OHMA) glucuronate, corresponding to one of the metabolites of MA, was synthesized from the commercially available methyl 4-hydroxyphenylacetate.

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Veröffentlicht in:Chemical & pharmaceutical bulletin 2005, Vol.53(6), pp.684-687
Hauptverfasser: Nakajima, Rika, Ono, Machiko, Aiso, Sadakazu, Akita, Hiroyuki
Format: Artikel
Sprache:eng
Schlagworte:
4-hydroxymethamphetamine
glucuronate
Glucuronides - chemical synthesis
Methamphetamine - analogs & derivatives
Methamphetamine - chemical synthesis
synthesis
Uronic Acids - chemical synthesis
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Beschreibung
Zusammenfassung:For the purpose of the direct characterization of the intact conjugated form in the urine of a methamphetamine (MA) abuser, 4-hydroxymethamphetamine (4-OHMA) glucuronate, corresponding to one of the metabolites of MA, was synthesized from the commercially available methyl 4-hydroxyphenylacetate.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.53.684