Preparation and Characterization of a Novel pH-Sensitive Ion Exchange Resin

Methylacrylic acid/styrene cross-linked with divinylbenzene is a novel pH-sensitive ion exchange resin. Microspheres of this resin were characterized by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The microspheres showed a pulsatile swelling behavior w...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2005, Vol.53(6), pp.631-633
Hauptverfasser:	Liu, Hongfei, Zhang, Shu, Nie, Shufang, Zhao, Xin, Sun, Xiyang, Yang, Xingang, Pan, Weisan
Format:	Artikel
Sprache:	eng
Schlagworte:	Hydrogen-Ion Concentration Ion Exchange ion exchange resin Ion Exchange Resins - analysis Ion Exchange Resins - chemical synthesis Ion Exchange Resins - pharmacokinetics Particle Size pH-sensitive poly(methylacrylic acid/styrene) pulsatile release
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Zusammenfassung:	Methylacrylic acid/styrene cross-linked with divinylbenzene is a novel pH-sensitive ion exchange resin. Microspheres of this resin were characterized by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The microspheres showed a pulsatile swelling behavior when the pH of the media changed. The pH-sensitive microspheres were loaded with salbutamol sulfate and the drug-release characteristics were studied under both simulated gastric and intestinal pH conditions. The results obtained showed that the drug release also depended on the pH of the release media.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.53.631