Effects of insulin on left ventricular function during dynamic exercise in overweight and obese subjects

Aims We designed this study in order to determine the effect of insulin on cardiac function in overweight and obese subjects during exercise. Methods and results The cardiac function of 62 normal glucose tolerant subjects, aged 30–40 and divided into normal weight (group 1, n=22, BMI 20–24.9 kg/m2), overweight (group 2, n=20, BMI 25–29.9 kg/m2), and obesity (group 3, n=20, BMI 30–35 kg/m2) was evaluated at rest and during dynamic exercise through angiocardioscintigraphy, when on hyperinsulinaemic euglycaemic clamp (test A) and when on normal saline infusion (test B). Left ventricular function at rest was statistically greater (P