4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17beta-hydroxysteroid dehydrogenase. Part 2. SAR

4,5-Disubstituted cis-pyrrolidinones were investigated as inhibitors of type II 17beta-hydroxysteroid dehydrogenase (17beta-HSD). Early structure-activity relationship patterns for this class of compounds are discussed.

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2005-06, Vol.15 (12), p.3053-3057
Hauptverfasser:	Gunn, David, Akuche, Christiana, Baryza, Jeremy, Blue, Marie-Louise, Brennan, Catherine, Campbell, Ann-Marie, Choi, Soongyu, Cook, James, Conrad, Patricia, Dixon, Brian, Dumas, Jacques, Ehrlich, Paul, Gane, Todd, Joe, Ted, Johnson, Jeffrey, Jordan, Jerold, Kramss, Richard, Liu, Peying, Levy, Joan, Lowe, Derek, McAlexander, Ian, Natero, Reina, Redman, Anikó M, Scott, William, Seng, Thomas, Sibley, Robert, Wang, Ming, Wang, Yamin, Wood, Jill, Zhang, Zhonghua
Format:	Artikel
Sprache:	eng
Schlagworte:	17-Hydroxysteroid Dehydrogenases - antagonists & inhibitors 17-Hydroxysteroid Dehydrogenases - metabolism Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Humans Pyrrolidinones - chemistry Pyrrolidinones - pharmacology Stereoisomerism Structure-Activity Relationship
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Zusammenfassung:	4,5-Disubstituted cis-pyrrolidinones were investigated as inhibitors of type II 17beta-hydroxysteroid dehydrogenase (17beta-HSD). Early structure-activity relationship patterns for this class of compounds are discussed.
ISSN:	0960-894X