Hybridization of Pyrrolidinyl Peptide Nucleic Acids and DNA:  Selectivity, Base-Pairing Specificity, and Direction of Binding

Hybridization of Pyrrolidinyl Peptide Nucleic Acids and DNA:  Selectivity, Base-Pairing Specificity, and Direction of Binding

A mixed-base, β-amino acid containing, pyrrolidinyl peptide nucleic acid (PNA) binds strongly and selectively to complementary DNA in an exclusively antiparallel fashion. The PNA−DNA binding specificity strictly follows the Watson−Crick base-pairing rules.

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Veröffentlicht in:Organic letters 2006-04, Vol.8 (9), p.1897-1900
Hauptverfasser: Vilaivan, Tirayut, Srisuwannaket, Choladda
Format: Artikel
Sprache:eng
Schlagworte:
Base Pairing
Base Sequence
DNA - chemistry
Molecular Structure
Nucleic Acid Hybridization
Peptide Nucleic Acids - chemical synthesis
Peptide Nucleic Acids - chemistry
Pyrrolidines - chemistry
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Zusammenfassung:A mixed-base, β-amino acid containing, pyrrolidinyl peptide nucleic acid (PNA) binds strongly and selectively to complementary DNA in an exclusively antiparallel fashion. The PNA−DNA binding specificity strictly follows the Watson−Crick base-pairing rules.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol060448q