Fiber-optic scanning two-photon fluorescence endoscope

We report on the development of a miniature, flexible, fiber-optic scanning endoscope for two-photon fluorescence imaging. The endoscope uses a tubular piezoelectric actuator for achieving two-dimensional beam scanning and a double-clad fiber for delivery of the excitation light and collection of tw...

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Veröffentlicht in:	Optics letters 2006-04, Vol.31 (8), p.1076-1078
Hauptverfasser:	THIRI MYAING, Mon, MACDONALD, Daniel J, XINGDE LI
Format:	Artikel
Sprache:	eng
Schlagworte:	Applied sciences Biological and medical sciences Circuit properties Electric, optical and optoelectronic circuits Electronics Endoscopes Equipment Design Equipment Failure Analysis Exact sciences and technology Fiber Optic Technology - instrumentation Fundamental and applied biological sciences. Psychology General aspects, investigation technics, apparatus Image Enhancement - instrumentation Image Interpretation, Computer-Assisted - instrumentation Integrated optics. Optical fibers and wave guides Microscopy, Confocal - instrumentation Microscopy, Fluorescence, Multiphoton - instrumentation Optical and optoelectronic circuits Optical Fibers Other fiber-optical devices Phantoms, Imaging Tissues, organs and organisms biophysics
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Beschreibung
Zusammenfassung:	We report on the development of a miniature, flexible, fiber-optic scanning endoscope for two-photon fluorescence imaging. The endoscope uses a tubular piezoelectric actuator for achieving two-dimensional beam scanning and a double-clad fiber for delivery of the excitation light and collection of two-photon fluorescence. Real-time imaging of fluorescent beads and cancer cells has been performed.
ISSN:	0146-9592 1539-4794
DOI:	10.1364/OL.31.001076