Microsatellite instability and p53 mutations are characteristic of subgroups of acute myeloid leukemia but independent events
Microsatellite instability (MSI) and p53 alterations which may represent major mechanisms of genetic instability, are rarely observed in de novo acute myeloid leukemia (AML) but may play a substantial role in subgroups characterized by either a myelodysplastic prephase (sAML), previous chemotherapy...
Gespeichert in:
| Veröffentlicht in: | Haematologica (Roma) 2005-05, Vol.90 (5), p.693-695 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 695 |
|---|---|
| container_issue | 5 |
| container_start_page | 693 |
| container_title | Haematologica (Roma) |
| container_volume | 90 |
| creator | Herzog, G Lu-Hesselmann, J Zimmermann, Y Haferlach, T Hiddemann, W Dreyling, M |
| description | Microsatellite instability (MSI) and p53 alterations which may represent major mechanisms of genetic instability, are rarely observed in de novo acute myeloid leukemia (AML) but may play a substantial role in subgroups characterized by either a myelodysplastic prephase (sAML), previous chemotherapy (tAML) or a complex aberrant karyotype. We performed allelotyping and p53 mutation analysis in 75 patients with morphologically and cytogenetically classified AML. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_67880955</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67880955</sourcerecordid><originalsourceid>FETCH-LOGICAL-h269t-f79e53c49f937bfabca3812221c4a7b7b643801049a05dd919c9982b1688dbd83</originalsourceid><addsrcrecordid>eNpF0EtLAzEQB_BFFFurX0Fy0dtCNunuZo5SfEHFi56XSTbbRvdlHi49-N1NsdLLPODHH2ZOknmWA0tFybLTZE450LSgpZglF859UMooQHmezPYo4wLmyc-LUXZw6HXbGq-J6Z1HaeK8I9jXZMw56YJHb4beEbSaqC1aVF5b47xRZGiIC3JjhzC6_YIqxJhup9vB1KTV4VN3BokMPmbXetSx9J7o71jdZXLWYOv01aEvkveH-7fVU7p-fXxe3a3TLSvAp00JOudqCQ3wUjYoFXKRMcYytcRSlrJYckEzugSkeV1DBgpAMJkVQtSyFnyR3P7ljnb4Ctr5qjNOxZOx10NwVVEKQSHPI7w-wCA7XVejNR3aXfX_sAhuDgCdwrax2Cvjjq4QjObAj25rNtvJWF25Dts2xrJqmiagVV4V0f0CW2CErw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67880955</pqid></control><display><type>article</type><title>Microsatellite instability and p53 mutations are characteristic of subgroups of acute myeloid leukemia but independent events</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Herzog, G ; Lu-Hesselmann, J ; Zimmermann, Y ; Haferlach, T ; Hiddemann, W ; Dreyling, M</creator><creatorcontrib>Herzog, G ; Lu-Hesselmann, J ; Zimmermann, Y ; Haferlach, T ; Hiddemann, W ; Dreyling, M</creatorcontrib><description>Microsatellite instability (MSI) and p53 alterations which may represent major mechanisms of genetic instability, are rarely observed in de novo acute myeloid leukemia (AML) but may play a substantial role in subgroups characterized by either a myelodysplastic prephase (sAML), previous chemotherapy (tAML) or a complex aberrant karyotype. We performed allelotyping and p53 mutation analysis in 75 patients with morphologically and cytogenetically classified AML.</description><identifier>ISSN: 0390-6078</identifier><identifier>EISSN: 1592-8721</identifier><identifier>PMID: 15921389</identifier><language>eng</language><publisher>Pavia: Haematologica</publisher><subject>Acute Disease ; Alleles ; Biological and medical sciences ; Cell Transformation, Neoplastic - genetics ; Chromosome Aberrations ; Chromosomes, Human - genetics ; Chromosomes, Human - ultrastructure ; Follow-Up Studies ; Genes, p53 ; Genotype ; Hematologic and hematopoietic diseases ; Humans ; Karyotyping ; Leukemia, Myeloid - classification ; Leukemia, Myeloid - genetics ; Leukemia, Myeloid - mortality ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Medical sciences ; Microsatellite Repeats ; Survival Analysis</subject><ispartof>Haematologica (Roma), 2005-05, Vol.90 (5), p.693-695</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16820593$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15921389$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Herzog, G</creatorcontrib><creatorcontrib>Lu-Hesselmann, J</creatorcontrib><creatorcontrib>Zimmermann, Y</creatorcontrib><creatorcontrib>Haferlach, T</creatorcontrib><creatorcontrib>Hiddemann, W</creatorcontrib><creatorcontrib>Dreyling, M</creatorcontrib><title>Microsatellite instability and p53 mutations are characteristic of subgroups of acute myeloid leukemia but independent events</title><title>Haematologica (Roma)</title><addtitle>Haematologica</addtitle><description>Microsatellite instability (MSI) and p53 alterations which may represent major mechanisms of genetic instability, are rarely observed in de novo acute myeloid leukemia (AML) but may play a substantial role in subgroups characterized by either a myelodysplastic prephase (sAML), previous chemotherapy (tAML) or a complex aberrant karyotype. We performed allelotyping and p53 mutation analysis in 75 patients with morphologically and cytogenetically classified AML.</description><subject>Acute Disease</subject><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Chromosome Aberrations</subject><subject>Chromosomes, Human - genetics</subject><subject>Chromosomes, Human - ultrastructure</subject><subject>Follow-Up Studies</subject><subject>Genes, p53</subject><subject>Genotype</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Leukemia, Myeloid - classification</subject><subject>Leukemia, Myeloid - genetics</subject><subject>Leukemia, Myeloid - mortality</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Medical sciences</subject><subject>Microsatellite Repeats</subject><subject>Survival Analysis</subject><issn>0390-6078</issn><issn>1592-8721</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0EtLAzEQB_BFFFurX0Fy0dtCNunuZo5SfEHFi56XSTbbRvdlHi49-N1NsdLLPODHH2ZOknmWA0tFybLTZE450LSgpZglF859UMooQHmezPYo4wLmyc-LUXZw6HXbGq-J6Z1HaeK8I9jXZMw56YJHb4beEbSaqC1aVF5b47xRZGiIC3JjhzC6_YIqxJhup9vB1KTV4VN3BokMPmbXetSx9J7o71jdZXLWYOv01aEvkveH-7fVU7p-fXxe3a3TLSvAp00JOudqCQ3wUjYoFXKRMcYytcRSlrJYckEzugSkeV1DBgpAMJkVQtSyFnyR3P7ljnb4Ctr5qjNOxZOx10NwVVEKQSHPI7w-wCA7XVejNR3aXfX_sAhuDgCdwrax2Cvjjq4QjObAj25rNtvJWF25Dts2xrJqmiagVV4V0f0CW2CErw</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>Herzog, G</creator><creator>Lu-Hesselmann, J</creator><creator>Zimmermann, Y</creator><creator>Haferlach, T</creator><creator>Hiddemann, W</creator><creator>Dreyling, M</creator><general>Haematologica</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20050501</creationdate><title>Microsatellite instability and p53 mutations are characteristic of subgroups of acute myeloid leukemia but independent events</title><author>Herzog, G ; Lu-Hesselmann, J ; Zimmermann, Y ; Haferlach, T ; Hiddemann, W ; Dreyling, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h269t-f79e53c49f937bfabca3812221c4a7b7b643801049a05dd919c9982b1688dbd83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acute Disease</topic><topic>Alleles</topic><topic>Biological and medical sciences</topic><topic>Cell Transformation, Neoplastic - genetics</topic><topic>Chromosome Aberrations</topic><topic>Chromosomes, Human - genetics</topic><topic>Chromosomes, Human - ultrastructure</topic><topic>Follow-Up Studies</topic><topic>Genes, p53</topic><topic>Genotype</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>Leukemia, Myeloid - classification</topic><topic>Leukemia, Myeloid - genetics</topic><topic>Leukemia, Myeloid - mortality</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Medical sciences</topic><topic>Microsatellite Repeats</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Herzog, G</creatorcontrib><creatorcontrib>Lu-Hesselmann, J</creatorcontrib><creatorcontrib>Zimmermann, Y</creatorcontrib><creatorcontrib>Haferlach, T</creatorcontrib><creatorcontrib>Hiddemann, W</creatorcontrib><creatorcontrib>Dreyling, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Haematologica (Roma)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Herzog, G</au><au>Lu-Hesselmann, J</au><au>Zimmermann, Y</au><au>Haferlach, T</au><au>Hiddemann, W</au><au>Dreyling, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microsatellite instability and p53 mutations are characteristic of subgroups of acute myeloid leukemia but independent events</atitle><jtitle>Haematologica (Roma)</jtitle><addtitle>Haematologica</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>90</volume><issue>5</issue><spage>693</spage><epage>695</epage><pages>693-695</pages><issn>0390-6078</issn><eissn>1592-8721</eissn><abstract>Microsatellite instability (MSI) and p53 alterations which may represent major mechanisms of genetic instability, are rarely observed in de novo acute myeloid leukemia (AML) but may play a substantial role in subgroups characterized by either a myelodysplastic prephase (sAML), previous chemotherapy (tAML) or a complex aberrant karyotype. We performed allelotyping and p53 mutation analysis in 75 patients with morphologically and cytogenetically classified AML.</abstract><cop>Pavia</cop><pub>Haematologica</pub><pmid>15921389</pmid><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0390-6078 |
| ispartof | Haematologica (Roma), 2005-05, Vol.90 (5), p.693-695 |
| issn | 0390-6078 1592-8721 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67880955 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acute Disease Alleles Biological and medical sciences Cell Transformation, Neoplastic - genetics Chromosome Aberrations Chromosomes, Human - genetics Chromosomes, Human - ultrastructure Follow-Up Studies Genes, p53 Genotype Hematologic and hematopoietic diseases Humans Karyotyping Leukemia, Myeloid - classification Leukemia, Myeloid - genetics Leukemia, Myeloid - mortality Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Microsatellite Repeats Survival Analysis |
| title | Microsatellite instability and p53 mutations are characteristic of subgroups of acute myeloid leukemia but independent events |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T16%3A07%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Microsatellite%20instability%20and%20p53%20mutations%20are%20characteristic%20of%20subgroups%20of%20acute%20myeloid%20leukemia%20but%20independent%20events&rft.jtitle=Haematologica%20(Roma)&rft.au=Herzog,%20G&rft.date=2005-05-01&rft.volume=90&rft.issue=5&rft.spage=693&rft.epage=695&rft.pages=693-695&rft.issn=0390-6078&rft.eissn=1592-8721&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E67880955%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67880955&rft_id=info:pmid/15921389&rfr_iscdi=true |