Microsatellite instability and p53 mutations are characteristic of subgroups of acute myeloid leukemia but independent events

Microsatellite instability (MSI) and p53 alterations which may represent major mechanisms of genetic instability, are rarely observed in de novo acute myeloid leukemia (AML) but may play a substantial role in subgroups characterized by either a myelodysplastic prephase (sAML), previous chemotherapy...

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Veröffentlicht in:	Haematologica (Roma) 2005-05, Vol.90 (5), p.693-695
Hauptverfasser:	Herzog, G, Lu-Hesselmann, J, Zimmermann, Y, Haferlach, T, Hiddemann, W, Dreyling, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Alleles Biological and medical sciences Cell Transformation, Neoplastic - genetics Chromosome Aberrations Chromosomes, Human - genetics Chromosomes, Human - ultrastructure Follow-Up Studies Genes, p53 Genotype Hematologic and hematopoietic diseases Humans Karyotyping Leukemia, Myeloid - classification Leukemia, Myeloid - genetics Leukemia, Myeloid - mortality Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Microsatellite Repeats Survival Analysis
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Zusammenfassung:	Microsatellite instability (MSI) and p53 alterations which may represent major mechanisms of genetic instability, are rarely observed in de novo acute myeloid leukemia (AML) but may play a substantial role in subgroups characterized by either a myelodysplastic prephase (sAML), previous chemotherapy (tAML) or a complex aberrant karyotype. We performed allelotyping and p53 mutation analysis in 75 patients with morphologically and cytogenetically classified AML.
ISSN:	0390-6078 1592-8721