Microbial Transformation of 20(S)-Protopanaxatriol by Mucor spinosus

Microbial biotransformation of 20(S)-protopanaxatriol (1) by the fungus Mucor spinosus (AS 3.3450) yielded four new metabolites, the structures of which were determined to be 12-oxo-15alpha-hydroxyl-20(S)-protopanaxatriol (2), 27-hydroxyl-20(S)-protopanaxatriol (3), 12-oxo-26-hydroxyl-20(S)-protopan...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2005-05, Vol.68 (5), p.678-680
Hauptverfasser:	TIAN, Yin, GUO, Hongzhu, HAN, Jian, GUO, Dean
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Applied microbiology Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Biotransformation Chemotherapic agents Drug Screening Assays, Antitumor Fundamental and applied biological sciences. Psychology Methods. Procedures. Technologies Microbiology Molecular Structure Mucor - metabolism Sapogenins - metabolism Sapogenins - pharmacology Stereoisomerism Triterpenes - metabolism Triterpenes - pharmacology
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Zusammenfassung:	Microbial biotransformation of 20(S)-protopanaxatriol (1) by the fungus Mucor spinosus (AS 3.3450) yielded four new metabolites, the structures of which were determined to be 12-oxo-15alpha-hydroxyl-20(S)-protopanaxatriol (2), 27-hydroxyl-20(S)-protopanaxatriol (3), 12-oxo-26-hydroxyl-20(S)-protopanaxatriol (4), and 12-oxo-27-hydroxyl-20(S)-protopanaxatriol (5), respectively, on the basis of their chemical and spectroscopic data. All the new metabolites, as well as the substrate, had significant cytotoxic effects on HL-60 cells (human leukemia cells).
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np049688+