Glaciapyrroles A, B, and C, Pyrrolosesquiterpenes from a Streptomyces sp. Isolated from an Alaskan Marine Sediment

A Streptomyces sp. (NPS008187) isolated from a marine sediment collected in Alaska was found to produce three new pyrrolosesquiterpenes, glyciapyrroles A (1), B (2), and C (3), along with the known diketopiperazines cyclo(leucyl-prolyl) (4), cyclo(isoleucyl-prolyl) (5), and cyclo(phenylalanyl-prolyl...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2005-05, Vol.68 (5), p.780-783
Hauptverfasser:	Macherla, Venkat R, Liu, Jehnan, Bellows, Christopher, Teisan, Sy, Nicholson, Benjamin, Lam, Kin S, Potts, Barbara C. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alaska Bacteriology Biological and medical sciences Fundamental and applied biological sciences. Psychology Geologic Sediments Marine Microbiology Molecular Structure Morphology, structure, chemical composition Nuclear Magnetic Resonance, Biomolecular Peptides, Cyclic - chemistry Peptides, Cyclic - isolation & purification Pyrroles - chemistry Pyrroles - isolation & purification Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Streptomyces Streptomyces - chemistry
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Beschreibung
Zusammenfassung:	A Streptomyces sp. (NPS008187) isolated from a marine sediment collected in Alaska was found to produce three new pyrrolosesquiterpenes, glyciapyrroles A (1), B (2), and C (3), along with the known diketopiperazines cyclo(leucyl-prolyl) (4), cyclo(isoleucyl-prolyl) (5), and cyclo(phenylalanyl-prolyl) (6). The structures of 1, 2, and 3 were established using spectroscopic methods.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np049597c