Iron overload is a major risk factor for severe infection after autologous stem cell transplantation : a study of 367 myeloma patients

We evaluated the risk factors for infection of 367 consecutive myeloma patients who underwent high-dose melphalan and autologous stem cell transplantation (ASCT). Examination of bone marrow iron stores (BMIS) prior to ASCT was used to evaluate body iron stores. Other variables included age, sex, act...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2006-05, Vol.37 (9), p.857-864
Hauptverfasser:	MICELI, M. H, DONG, L, GRAZZIUTTI, M. L, FASSAS, A, THERTULIEN, R, VAN RHEE, F, BARLOGIE, B, ANAISSIE, E. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Angiogenesis Inhibitors - therapeutic use Autografts Bacteremia Biological and medical sciences Bone marrow Bone marrow transplantation Bone marrow, stem cells transplantation. Graft versus host reaction Care and treatment Chemotherapy Colitis Diagnosis Evaluation Female Gender Health aspects Health risks Hematopoietic stem cells Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Infection - epidemiology Infections Iron Iron in the body Iron Overload - complications Iron Overload - etiology Leukocytes (neutrophilic) Male Medical sciences Melphalan Middle Aged Mucositis Multiple myeloma Multiple Myeloma - drug therapy Multiple Myeloma - therapy Multivariate Analysis Myeloma Neutropenia Patient outcomes Remission Risk analysis Risk factors Septic shock Smoking Stem cell transplantation Stem Cell Transplantation - adverse effects Stem cells Thalidomide - therapeutic use Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation
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Zusammenfassung:	We evaluated the risk factors for infection of 367 consecutive myeloma patients who underwent high-dose melphalan and autologous stem cell transplantation (ASCT). Examination of bone marrow iron stores (BMIS) prior to ASCT was used to evaluate body iron stores. Other variables included age, sex, active smoking, myeloma remission status, severity of mucositis and duration of severe neutropenia post-ASCT (
ISSN:	0268-3369 1476-5365
DOI:	10.1038/sj.bmt.1705340