Urotensin II in patients with chronic heart failure

Urotensin II in patients with chronic heart failure

Background: Human Urotensin II (hU‐II) is the most potent vasoconstrictor known to date. HU‐II receptors are predominant in the human heart and arterial vessels, suggesting hU‐II to be of importance as a cardiovascular mediator. Methods: We studied 32 consecutive patients (60±12 years) with chronic...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:European journal of heart failure 2005-06, Vol.7 (4), p.475-478
Hauptverfasser: Krüger, Stefan, Graf, Jürgen, Kunz, Dagmar, Stickel, Tina, Merx, Marc W., Hanrath, Peter, Janssens, Uwe
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Chronic heart failure
Endothelin-1 - blood
Endothelin-exercise
Exercise - physiology
Female
Heart Failure - blood
Humans
Male
Middle Aged
Oxygen Consumption
Stroke Volume
Urotensin II
Urotensins - blood
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Background: Human Urotensin II (hU‐II) is the most potent vasoconstrictor known to date. HU‐II receptors are predominant in the human heart and arterial vessels, suggesting hU‐II to be of importance as a cardiovascular mediator. Methods: We studied 32 consecutive patients (60±12 years) with chronic heart failure (CHF) and 10 control subjects (54±12 years, n.s.) with cardiopulmonary exercise testing. Blood samples for the measurement of plasma hU‐II and big‐endothelin‐1 (big‐ET1) were obtained at rest and at peak exercise. Results: Peak VO2 was significantly higher in controls than in CHF patients (19.8±3.8 vs. 14.7±3.6 ml min−1 kg−1, P
ISSN:1388-9842
1879-0844
DOI:10.1016/S1388-9842(03)00106-5