Polymorphonuclear Leukocytes May Impair Endothelial Function: Results of Crossover Randomized Study of Lipid-Lowering Therapies

OBJECTIVES—To examine whether polymorphonuclear leukocytes (PMNs) in hypercholesterolemia (HC) are activated to generate large amount of superoxide in vivo and hence impair endothelial function and, if so, whether statins, which possess anti-inflammatory properties, may restore PMN-mediated endothel...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2005-06, Vol.25 (6), p.1262-1267
Hauptverfasser:	Sugano, Ryo, Matsuoka, Hidehiro, Haramaki, Nobuya, Umei, Hidekazu, Murase, Eiko, Fukami, Kei, Iida, Shuji, Ikeda, Hisao, Imaizumi, Tsutomu
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticholesteremic Agents - administration & dosage Atherosclerosis (general aspects, experimental research) Atherosclerosis - drug therapy Atherosclerosis - immunology Biological and medical sciences Blood and lymphatic vessels Blood. Blood coagulation. Reticuloendothelial system Cardiology. Vascular system Cardiovascular system Cell Adhesion - drug effects Cell Adhesion - immunology Cholesterol, LDL - blood Cross-Over Studies Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Endothelium, Vascular - cytology Endothelium, Vascular - immunology Endothelium, Vascular - metabolism Epichlorohydrin - administration & dosage Fatty Acids, Monounsaturated - administration & dosage Female Humans Hypercholesterolemia - drug therapy Hypercholesterolemia - immunology Imidazoles - administration & dosage Indoles - administration & dosage Lipoproteins, LDL - metabolism Male Medical sciences Middle Aged Neutrophils - cytology Neutrophils - drug effects Neutrophils - immunology Nitric Oxide Synthase Type III - metabolism Pharmacology. Drug treatments Phosphorylation Resins, Synthetic - administration & dosage Serine - metabolism Superoxides - metabolism Vasodilation - drug effects Vasodilator agents. Cerebral vasodilators
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Zusammenfassung:	OBJECTIVES—To examine whether polymorphonuclear leukocytes (PMNs) in hypercholesterolemia (HC) are activated to generate large amount of superoxide in vivo and hence impair endothelial function and, if so, whether statins, which possess anti-inflammatory properties, may restore PMN-mediated endothelial dysfunction. METHODS AND RESULTS—At baseline, subjects with HC showed impaired endothelial function (P
ISSN:	1079-5642 1524-4636
DOI:	10.1161/01.ATV.0000163842.91226.ba