Ontogeny of Regeneration of β-Cells in the Neonatal Rat after Treatment with Streptozotocin

We induced partial β-cell loss within the pancreas of neonatal rats using streptozotocin (STZ) to better characterize the mechanisms leading to β-cell regeneration postnatally. Rats were administered either STZ (70 mg/kg) or buffer alone on postnatal d 4, and the endocrine pancreas was examined betw...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2006-05, Vol.147 (5), p.2346-2356
Hauptverfasser:	Thyssen, Sandra, Arany, Edith, Hill, D. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Beta cells Biological and medical sciences Cell Proliferation DNA Primers - chemistry Female Fundamental and applied biological sciences. Psychology Glucagon Glucagon - chemistry Glucagon - metabolism Glucose Glucose - metabolism Glucose tolerance Glucose transporter Homeobox Hyperglycemia Hyperplasia Immunohistochemistry Insulin Insulin - metabolism Insulin-Secreting Cells - physiology Islets of Langerhans - metabolism Male Mice Microscopy, Fluorescence mRNA Neonates Ontogeny Pancreas Pancreas - metabolism Phenotypes Polypeptides Proglucagon - metabolism Radioimmunoassay Rats Rats, Wistar Regeneration Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Streptozocin Streptozocin - pharmacology Time Factors Vertebrates: endocrinology
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Beschreibung
Zusammenfassung:	We induced partial β-cell loss within the pancreas of neonatal rats using streptozotocin (STZ) to better characterize the mechanisms leading to β-cell regeneration postnatally. Rats were administered either STZ (70 mg/kg) or buffer alone on postnatal d 4, and the endocrine pancreas was examined between 4 and 40 d later. STZ-treated rats showed an approximately 60% loss of existing β-cells and a moderate hyperglycemia (
ISSN:	0013-7227 1945-7170
DOI:	10.1210/en.2005-0396