Allicin, the active component of garlic, prevents immune-mediated, concanavalin A-induced hepatic injury in mice

: Background/Aim: Allicin, the immunologically active component of garlic, has been found to affect oxidative stress and immune response in several experimental systems. In the present study, we examined the ability of allicin to prevent immune‐mediated, concanavalin A (Con A)‐induced liver damage in mice. Methods: Mice were pretreated with allicin for 7 days before their inoculation with Con A (15 mg/kg). The serum levels of liver enzymes and liver histology were examined 24 h after Con A administration. The effect of Con A and allicin on serum levels of tumor necrosis factor‐α (TNF‐α) and nuclear factor‐κB (NF‐κB) activation in the liver were examined 2 h after Con A administration, in a separate group of rats, and the effect of allicin on Con A‐induced expression of inducible nitric oxide synthase (iNOS) was determined by western blot analysis 24 h after Con A injection. Results: The histopathologic damage in the mouse livers, and the Con A‐induced increase of aminotransferases and TNF‐α were markedly inhibited in the mice pretreated with allicin before Con A injection (P