Derivatization Does Not Influence Antimicrobial and Antifungal Activities of Applanoxidic Acids and Sterols from Ganoderma spp

Applanoxidic acids and sterols, isolated from Ganoderma spp., were acetylated and/or methylated. The antibacterial activity against Escherichia coli and Staphylococcus aureus and the antifungal activity against Candida albicans and Trichophyton mentagrophytes of the derivatives were investigated by...

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Veröffentlicht in:	Zeitschrift für Naturforschung C. A journal of biosciences 2006-01, Vol.61 (1), p.31-34
Hauptverfasser:	Smania, Artur, Smania, Elza F. A., Monache, Franco Delle, Pizzolatti, Moacir G., Monache, Giuliano Delle
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibacterial and Antifungal Activity Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Applanoxidic Acids Arthrodermataceae - drug effects Candida albicans - drug effects Derivatization Escherichia coli - drug effects Ganoderma - chemistry Ganoderma - isolation & purification Microbial Sensitivity Tests Staphylococcus aureus - drug effects Sterols Sterols - isolation & purification Sterols - pharmacology Trichophyton - drug effects Triterpenes - isolation & purification Triterpenes - pharmacology
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Zusammenfassung:	Applanoxidic acids and sterols, isolated from Ganoderma spp., were acetylated and/or methylated. The antibacterial activity against Escherichia coli and Staphylococcus aureus and the antifungal activity against Candida albicans and Trichophyton mentagrophytes of the derivatives were investigated by a microdilution method, and compared with those of the natural products. Both natural and modified compounds exhibited comparable antibacterial and antifungal activities in a range of 1.0 to > 2.0 mg/ml minimal inhibitory concentration
ISSN:	0939-5075 1865-7125
DOI:	10.1515/znc-2006-1-206