Chronic stimulation of the subthalamic nucleus increases daily on-time without dyskinesia in advanced Parkinson's disease

We assessed the efficacy of chronic stimulation of the subthalamic nucleus (STN-DBS) in 20 patients with Parkinson's disease (PD) by means of clinical assessments and patient diaries 12 months after surgery. STN-DBS reduced the UPDRS part III off-medication score by 33%, and successively improv...

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Veröffentlicht in:Parkinsonism & related disorders 2006-04, Vol.12 (3), p.143-148
Hauptverfasser: Portman, A.T., Laar, T.van, Staal, M.J., Rutgers, A.W.F., Journee, H.L., Leenders, K.L.
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Sprache:eng
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Zusammenfassung:We assessed the efficacy of chronic stimulation of the subthalamic nucleus (STN-DBS) in 20 patients with Parkinson's disease (PD) by means of clinical assessments and patient diaries 12 months after surgery. STN-DBS reduced the UPDRS part III off-medication score by 33%, and successively improved complete daily on-time without dyskinesia at 12 months significantly. In conclusion, our study demonstrates the efficacy of chronic STN-DBS on motor features in a selected population of advanced PD patients. In addition to clinical assessments, patients' diaries serve as an essential tool to evaluate the functional motor status after STN-DBS.
ISSN:1353-8020
1873-5126
DOI:10.1016/j.parkreldis.2005.10.007