Mammalian defensins in the antimicrobial immune response

Mammalian defensins in the antimicrobial immune response

Defensins are peptidic components of the innate immune system of plants and animals. In mammals, defensins have evolved to have a central function in the host defense properties of granulocytic leukocytes, mucosal surfaces, skin and other epithelia. This review focuses on the biological functions of...

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Veröffentlicht in:Nature immunology 2005-06, Vol.6 (6), p.551-557
Hauptverfasser: Selsted, Michael E, Ouellette, Andre J
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biomedical and Life Sciences
Biomedicine
Defensins - chemistry
Defensins - classification
Defensins - genetics
Defensins - immunology
Gene Expression
Humans
Immune response
Immune system
Immunity, Innate
Immunology
Infectious Diseases
Mammals
Models, Molecular
Molecular Structure
review-article
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Beschreibung
Zusammenfassung:Defensins are peptidic components of the innate immune system of plants and animals. In mammals, defensins have evolved to have a central function in the host defense properties of granulocytic leukocytes, mucosal surfaces, skin and other epithelia. This review focuses on the biological functions of three structural subgroups of mammalian defensins and the evidence for their involvement as effectors of antimicrobial innate immunity.
ISSN:1529-2908
1529-2916
DOI:10.1038/ni1206