New inhibitors of rabbit muscle triose-phosphate isomerase

We describe the synthesis and evaluation of three new competitive inhibitors of triose-phosphate isomerase. One of them (phosphoglycoloamidoxime 3a: K i = 4.5 μM) is among the best reversible inhibitors so far reported for this enzyme. We describe the synthesis and evaluation of three new competitiv...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2005-06, Vol.15 (11), p.2906-2909
Hauptverfasser:	Fonvielle, M., Mariano, S., Therisod, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Class II fructose-bisphosphate aldolase Enzyme inhibitor Enzyme Inhibitors - pharmacology Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Isomerases Medical sciences Miscellaneous Muscle, Skeletal - drug effects Muscle, Skeletal - enzymology Pharmacology. Drug treatments Phosphoglycoloamidoxyme Phosphoglycolohydrazide Phosphonate inhibitors Rabbits Triose-phosphate isomerase Triose-Phosphate Isomerase - antagonists & inhibitors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We describe the synthesis and evaluation of three new competitive inhibitors of triose-phosphate isomerase. One of them (phosphoglycoloamidoxime 3a: K i = 4.5 μM) is among the best reversible inhibitors so far reported for this enzyme. We describe the synthesis and evaluation of three new competitive inhibitors of triose-phosphate isomerase. One of them (phosphoglycoloamidoxime: K i = 4.5 μM) is among the best reversible inhibitors so far reported for this enzyme.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2005.03.061