Simultaneous determination of paclitaxel and a new P-glycoprotein inhibitor HM-30181 in rat plasma by liquid chromatography with tandem mass spectrometry

An LC‐MS/MS method for the simultaneous determination of a new P‐glycoprotein inhibitor 4‐oxo‐4H‐chromene‐2‐carboxylic acid [2‐(2‐{4‐[2‐(6,7‐dimethoxy‐3,4‐dihydro‐1H‐isoquinolin‐2‐yl)‐ethyl]‐phenyl

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Veröffentlicht in:	Journal of separation science 2006-03, Vol.29 (5), p.628-634
Hauptverfasser:	Paek, In Bok, Ji, Hye Young, Kim, Maeng Seop, Lee, Gwan Sun, Lee, Hye Suk
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antineoplastic Agents, Phytogenic - blood Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacokinetics ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors Benzopyrans - blood Benzopyrans - chemistry Benzopyrans - pharmacokinetics Biological and medical sciences Chromatography, Liquid - methods General pharmacology HM-30181 Isoquinolines - blood Isoquinolines - chemistry Isoquinolines - pharmacokinetics LC-MS/MS Male Medical sciences Molecular Structure P-glycoprotein inhibitor Paclitaxel Paclitaxel - blood Paclitaxel - chemistry Paclitaxel - pharmacokinetics Pharmacology. Drug treatments Plasma Rats Rats, Sprague-Dawley Reference Standards Reproducibility of Results Sensitivity and Specificity Tandem Mass Spectrometry - methods Tetrazoles - blood Tetrazoles - chemistry Tetrazoles - pharmacokinetics
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Zusammenfassung:	An LC‐MS/MS method for the simultaneous determination of a new P‐glycoprotein inhibitor 4‐oxo‐4H‐chromene‐2‐carboxylic acid [2‐(2‐{4‐[2‐(6,7‐dimethoxy‐3,4‐dihydro‐1H‐isoquinolin‐2‐yl)‐ethyl]‐phenyl
ISSN:	1615-9306 1615-9314
DOI:	10.1002/jssc.200500368