Predictive factors of bleeding and thrombosis during induction therapy in acute promyelocytic leukemia—a single center experience in 34 patients

In this retrospective study, the hemorrhagic and thrombotic events are reported at presentation and during induction in 34 consecutive acute promyelocytic leukemia (APL) patients treated in a single referral center. The most consistent hemostatic abnormality was decreased fibrinogen level (

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Bibliographische Detailangaben
Veröffentlicht in:	Thrombosis research 2005, Vol.116 (2), p.109-114
Hauptverfasser:	Dally, Najib, Hoffman, Ron, Haddad, Nuhad, Sarig, Galit, Rowe, Jacob M., Brenner, Benjamin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute promyelocytic leukemia Adolescent Adult Aged Aged, 80 and over Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use ATRA Biological and medical sciences Bleeding Blood and lymphatic vessels Blood Coagulation Tests Blood. Blood coagulation. Reticuloendothelial system Cardiology. Vascular system Coronary heart disease Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Female Fibrinogen - analysis Heart Hemorrhage - diagnosis Hemorrhage - etiology Humans Leukemia, Promyelocytic, Acute - complications Leukemia, Promyelocytic, Acute - drug therapy Leukocyte Count Male Medical sciences Middle Aged Pharmacology. Drug treatments Platelet Count Predictive Value of Tests Retrospective Studies Risk Factors Thrombophilia Thrombophilia - complications Thrombosis - diagnosis Thrombosis - etiology
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Beschreibung
Zusammenfassung:	In this retrospective study, the hemorrhagic and thrombotic events are reported at presentation and during induction in 34 consecutive acute promyelocytic leukemia (APL) patients treated in a single referral center. The most consistent hemostatic abnormality was decreased fibrinogen level (
ISSN:	0049-3848 1879-2472
DOI:	10.1016/j.thromres.2004.11.001