Effect of the anticancer drug oracin on mouse liver topoisomerases I and II

The inhibitory effect of oracin on the activities of topoisomerases I and II isolated from the nuclei of mice liver tissue was studied. This drug showed a 100% inhibitory effect at 5 μm and 50% inhibition at 1 μm on topoisomerase II activity, while the activity of topoisomerase I at these concentrat...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2005-05, Vol.57 (5), p.657-659
Hauptverfasser:	Stuchlík, Stanislav, Turn̂a, Ján, Miko, Milan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Cell Nucleus - drug effects Cell Nucleus - enzymology Enzyme Inhibitors - pharmacology Ethanolamines - pharmacology In Vitro Techniques Isoquinolines - pharmacology Liver - cytology Liver - drug effects Liver - enzymology Male Mice Topoisomerase I Inhibitors Topoisomerase II Inhibitors
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Zusammenfassung:	The inhibitory effect of oracin on the activities of topoisomerases I and II isolated from the nuclei of mice liver tissue was studied. This drug showed a 100% inhibitory effect at 5 μm and 50% inhibition at 1 μm on topoisomerase II activity, while the activity of topoisomerase I at these concentrations was not inhibited.
ISSN:	0022-3573 2042-7158
DOI:	10.1211/0022357055858