Benzimidazolyl quinolinyl mercaptotriazoles as potential antimicrobial and antiviral agents

Condensation of ethylaceto acetate (EAA) with resorcinol in concentrated H2SO4 afforded 7-hydroxy-4-methyl coumarin (1), which on reaction with thiosemicarbazide in anhydrous pyridine yielded 7-hydroxy-4-methyl-quinolinyl [1,5-c]-mercaptotriazole (2). Reaction of 2 with formaldehyde solution and ami...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Acta pharmaceutica (Zagreb, Croatia) Croatia), 2005-03, Vol.55 (1), p.47-56
Hauptverfasser:	Pandey, Vinod Kumar, Upadhyay, Mridula, Upadhyay, Mrinalini, Gupta, Vishnu Dev, Tandon, Meenal
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Infective Agents - chemical synthesis Anti-Infective Agents - pharmacology Drug Evaluation, Preclinical Encephalitis Virus, Japanese - drug effects Enterococcus faecalis - drug effects Escherichia coli - drug effects Fungi - drug effects Herpesvirus 1, Human - drug effects Klebsiella pneumoniae - drug effects Mice Pseudomonas aeruginosa - drug effects Quinolines - chemical synthesis Quinolines - pharmacology Staphylococcus aureus - drug effects Triazoles - chemical synthesis Triazoles - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Condensation of ethylaceto acetate (EAA) with resorcinol in concentrated H2SO4 afforded 7-hydroxy-4-methyl coumarin (1), which on reaction with thiosemicarbazide in anhydrous pyridine yielded 7-hydroxy-4-methyl-quinolinyl [1,5-c]-mercaptotriazole (2). Reaction of 2 with formaldehyde solution and amino acid in ethanol yielded 7-hydroxy-4-methyl-8-(N-methyl-aminoacid)-quinolinyl [1,5-c]-2''-mercaptotriazole (3a-e). Interaction of 3 with o-phenylenediamine in pyridine yielded 7-hydroxy-4-methyl-8-(aminobenzimidazolyl)-quinolinyl [1,5-c]-2''-mercaptotriazole derivatives (4a-e). The latter compounds were evaluated for their antiviral and antimicrobial activities.
ISSN:	1330-0075