Temporary Phosphate Tethers:  A Metathesis Strategy to Differentiated Polyol Subunits

Temporary Phosphate Tethers:  A Metathesis Strategy to Differentiated Polyol Subunits

Studies probing reactivity and selectivity of cross metathesis (CM) with an exocyclic olefin in a P-chiral bicyclo[4.3.1]phosphate triester are described. Studies have revealed a Type III CM reactivity pattern for the exocyclic olefin within this phosphate triester. This versatile method allows for...

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Veröffentlicht in:Organic letters 2006-04, Vol.8 (8), p.1673-1676
Hauptverfasser: Waetzig, Joshua D, Hanson, Paul R
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes - chemistry
Molecular Structure
Organophosphorus Compounds - chemistry
Polymers - chemical synthesis
Polymers - chemistry
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Zusammenfassung:Studies probing reactivity and selectivity of cross metathesis (CM) with an exocyclic olefin in a P-chiral bicyclo[4.3.1]phosphate triester are described. Studies have revealed a Type III CM reactivity pattern for the exocyclic olefin within this phosphate triester. This versatile method allows for simple, selective manipulation of a P-chiral building block en route to advanced polyol subunits.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0602809