Asymmetric Friedel−Crafts Addition of Indoles to N-Sulfonyl Aldimines:  A Simple Approach to Optically Active 3-Indolyl-methanamine Derivatives

Asymmetric Friedel−Crafts Addition of Indoles to N-Sulfonyl Aldimines:  A Simple Approach to Optically Active 3-Indolyl-methanamine Derivatives

The enantioselective copper(II)-catalyzed Friedel−Crafts addition of indoles to N-sulfonyl aldimines was developed using chiral bisoxazoline as ligands, and high enantioselectivities (up to 96% ee) were achieved.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2006-04, Vol.8 (8), p.1621-1624
Hauptverfasser: Jia, Yi-Xia, Xie, Jian-Hua, Duan, Hai-Feng, Wang, Li-Xin, Zhou, Qi-Lin
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The enantioselective copper(II)-catalyzed Friedel−Crafts addition of indoles to N-sulfonyl aldimines was developed using chiral bisoxazoline as ligands, and high enantioselectivities (up to 96% ee) were achieved.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0602001