Mediator and the mechanism of transcriptional activation

Mediator was discovered because of its activity in a yeast RNA polymerase II (pol II) transcription system – it is needed for the system to respond to a transcriptional activator. Mediator is the central link in the enhancer→activator→Mediator→pol II→promoter pathway. The transduction of regulatory...

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Veröffentlicht in:	Trends in biochemical sciences (Amsterdam. Regular ed.) 2005-05, Vol.30 (5), p.235-239
1. Verfasser:	Kornberg, Roger D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Fungal Proteins - genetics Fungal Proteins - metabolism Humans Multiprotein Complexes - metabolism RNA Polymerase II - metabolism Trans-Activators - metabolism Transcription Factors - metabolism Transcription, Genetic Transcriptional Activation
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Mediator was discovered because of its activity in a yeast RNA polymerase II (pol II) transcription system – it is needed for the system to respond to a transcriptional activator. Mediator is the central link in the enhancer→activator→Mediator→pol II→promoter pathway. The transduction of regulatory signals through this pathway is crucial for transcription of almost all pol II promoters in all eukaryote organisms.
ISSN:	0968-0004 1362-4326
DOI:	10.1016/j.tibs.2005.03.011