Epoxytwinol A, a novel unique angiogenesis inhibitor with C2 symmetry, produced by a fungus

We isolated a novel unique pentaketide dimer designated as epoxytwinol A from the fermentation broth of a fungus. The structure of epoxytwinol A was determined to have a new carbon skeleton with C(2) symmetry by elucidation of spectroscopic evidence. Epoxytwinol A inhibited endothelial cell migratio...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2005-05 (20), p.2575-2577
Hauptverfasser:	Kakeya, Hideaki, Onose, Rie, Koshino, Hiroyuki, Osada, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - chemistry Angiogenesis Inhibitors - pharmacology Cell Movement - drug effects Cells, Cultured Dimerization Dose-Response Relationship, Drug Endothelial Cells - drug effects Epoxy Compounds - chemistry Epoxy Compounds - pharmacology Fungi - chemistry Humans Hydroquinones - chemistry Hydroquinones - pharmacology Molecular Conformation
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Beschreibung
Zusammenfassung:	We isolated a novel unique pentaketide dimer designated as epoxytwinol A from the fermentation broth of a fungus. The structure of epoxytwinol A was determined to have a new carbon skeleton with C(2) symmetry by elucidation of spectroscopic evidence. Epoxytwinol A inhibited endothelial cell migration stimulated by vascular endothelial growth factor (ED(100)= 2.6 microM).
ISSN:	1359-7345 1364-548X
DOI:	10.1039/b501392e