Haemodynamic, acid–base and blood volume changes during prolonged low pressure pneumoperitoneum in rabbits

The anaesthetic management of small infants during advanced laparoscopic surgery can be complicated by the major pathophysiological effects of increased intra-abdominal pressure. In this study haemodynamic, acid–base and blood volume changes were investigated during pneumoperitoneum in a small anima...

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Veröffentlicht in:British journal of anaesthesia : BJA 2006-05, Vol.96 (5), p.563-568
Hauptverfasser: Sümpelmann, R., Schuerholz, T., Marx, G., Härtel, D., Hecker, H., Ure, B.M., Jesch, N.K.
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Sprache:eng
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Zusammenfassung:The anaesthetic management of small infants during advanced laparoscopic surgery can be complicated by the major pathophysiological effects of increased intra-abdominal pressure. In this study haemodynamic, acid–base and blood volume changes were investigated during pneumoperitoneum in a small animal model. Ten fasted, anaesthetized, mechanically ventilated and multi-catheterized New Zealand rabbits were randomized to carbon dioxide pneumoperitoneum (PP, duration 210 min, pressure 8 mm Hg) or control group. Cardiac index was determined using trans-cardiopulmonary thermodilution and total blood volume was measured by thermal-dye dilution with indocyanine green using a fibreoptic monitor system. In PP cardiac index (CI), central venous oxygen saturation (ScvO2), total blood volume (TBV) and base excess (BE) decreased significantly during the study whereas all variables remained constant in the control group. After release of PP the measured variables did not return to baseline within 30 min [PP, baseline vs study end: CI 108 (22) vs 85 (14) ml kg−1 min−1, ScvO2 81.4 (8.9) vs 56.7 (9.8)%, TBV 318 (69) vs 181 (54) ml, BE −1.9 (2.7) vs −8.7 (1.8) mmol litre−1; P
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/ael045