Inhibition of matrix metalloproteinase-9 by "multi-prong" surface binding groups

A novel strategy of blocking the active site accessibility of MMP-9 by "multi-prong" surface binding groups is described.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2005-05 (20), p.2549-2551
Hauptverfasser:	Banerjee, Abir L, Tobwala, Shakila, Haldar, Manas K, Swanson, Michael, Roy, Bidhan C, Mallik, Sanku, Srivastava, D K
Format:	Artikel
Sprache:	eng
Schlagworte:	Copper - chemistry Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Imino Acids - chemistry Matrix Metalloproteinase 10 Matrix Metalloproteinase 9 - chemistry Matrix Metalloproteinase Inhibitors Metalloendopeptidases - antagonists & inhibitors Metalloendopeptidases - chemistry Models, Molecular Molecular Structure Organometallic Compounds - chemistry Organometallic Compounds - pharmacology Structure-Activity Relationship Surface Properties
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Beschreibung
Zusammenfassung:	A novel strategy of blocking the active site accessibility of MMP-9 by "multi-prong" surface binding groups is described.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/b501780g