Hemodynamic Mechanisms Underlying the Incomplete Tolerance to Caffeine's Pressor Effects

Hemodynamic Mechanisms Underlying the Incomplete Tolerance to Caffeine's Pressor Effects

Blood pressure (BP) and cardiovascular hemodynamics were assessed at baseline and after caffeine administration in a 4-week, placebo-controlled, double-blind, randomized, crossover trial of caffeine tolerance formation. Half of the subjects developed tolerance to the pressor effect of caffeine, wher...

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Veröffentlicht in:The American journal of cardiology 2005-06, Vol.95 (11), p.1389-1392
Hauptverfasser: Farag, Noha H., Vincent, Andrea S., McKey, Barbara S., Whitsett, Thomas L., Lovallo, William R.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Biological and medical sciences
Blood pressure
Blood Pressure - drug effects
Caffeine
Caffeine - pharmacology
Cardiology
Cardiology. Vascular system
Clinical trials
Cross-Over Studies
Double-Blind Method
Drug Tolerance
Female
Hemodynamics - drug effects
Humans
Male
Medical sciences
Vascular Resistance - drug effects
Vasoconstrictor Agents - pharmacology
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Beschreibung
Zusammenfassung:Blood pressure (BP) and cardiovascular hemodynamics were assessed at baseline and after caffeine administration in a 4-week, placebo-controlled, double-blind, randomized, crossover trial of caffeine tolerance formation. Half of the subjects developed tolerance to the pressor effect of caffeine, whereas the other half continued to show increases in BP after caffeine ingestion (F = 16.7, p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2005.01.093