A New Total Synthesis of Porritoxin

A New Total Synthesis of Porritoxin

A concise and efficient total synthesis of the phytotoxin porritoxin is described. The key step of the synthesis is based upon a Parham cyclization methodology which enables the creation of the lactam unit embedded in the title compound framework with the concomitant formation of the tethered hydrox...

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Veröffentlicht in:Journal of organic chemistry 2006-04, Vol.71 (8), p.3303-3305
Hauptverfasser: Moreau, Anne, Lorion, Magali, Couture, Axel, Deniau, Eric, Grandclaudon, Pierre
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with only one n hetero atom and condensed derivatives
Indoles - chemical synthesis
Indoles - chemistry
Isoindoles
Molecular Structure
Organic chemistry
Preparations and properties
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Beschreibung
Zusammenfassung:A concise and efficient total synthesis of the phytotoxin porritoxin is described. The key step of the synthesis is based upon a Parham cyclization methodology which enables the creation of the lactam unit embedded in the title compound framework with the concomitant formation of the tethered hydroxyakyl chain.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo052592f