Enhancement of folate receptor α expression in tumor cells through the glucocorticoid receptor : A promising means to improved tumor detection and targeting

The utility of the folate receptor (FR) type alpha, in a broad range of targeted therapies and as a diagnostic serum marker in cancer, is confounded by its variable tumor expression levels. FR-alpha, its mRNA and its promoter activity were coordinately up-regulated by the glucocorticoid receptor (GR...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2005-05, Vol.65 (10), p.4431-4441
Hauptverfasser:	TRAN, Thuyet, SHATNAWI, Aymen, XUAN ZHENG, KELLEY, Karen M. M, RATNAM, Manohar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Base Sequence Biological and medical sciences Carrier Proteins - biosynthesis Carrier Proteins - genetics Cycloheximide - pharmacology Dexamethasone - pharmacology Female Folate Receptors, GPI-Anchored Gene Expression Regulation - drug effects HeLa Cells Histone Deacetylase Inhibitors Humans Hydroxamic Acids - pharmacology Medical sciences Mice Mice, SCID Mifepristone - pharmacology Molecular Sequence Data Pharmacology. Drug treatments Promoter Regions, Genetic - drug effects Receptors, Cell Surface - biosynthesis Receptors, Cell Surface - genetics Receptors, Glucocorticoid - metabolism Receptors, Glucocorticoid - physiology Tumors Xenograft Model Antitumor Assays
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Zusammenfassung:	The utility of the folate receptor (FR) type alpha, in a broad range of targeted therapies and as a diagnostic serum marker in cancer, is confounded by its variable tumor expression levels. FR-alpha, its mRNA and its promoter activity were coordinately up-regulated by the glucocorticoid receptor (GR) agonist, dexamethasone. Optimal promoter activation which occurred at
ISSN:	0008-5472 1538-7445
DOI:	10.1158/0008-5472.CAN-04-2890