Safety of low-dose low-molecular-weight-heparins in thrombocytopenic stem cell transplantation patients : a case series and review of the literature

Safety of low-dose low-molecular-weight-heparins in thrombocytopenic stem cell transplantation patients : a case series and review of the literature

Few attempts have been made to examine the feasibility of safely administering low-molecular-weight-heparins (LMWHs) in the presence of concurrent thrombocytopenia. We retrospectively investigated the safety of low-dose LMWH in BMT patients, a population at risk of bleeding. In total, 26 patients re...

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Veröffentlicht in:Bone marrow transplantation (Basingstoke) 2005-06, Vol.35 (11), p.1071-1077
Hauptverfasser: IBRAHIM, R. B, PERES, E, DANSEY, R, ABIDI, M. H, ABELLA, E. M, GUMMA, M. M, MILAN, N, SMITH, D. W, HEILBRUN, L. K, KLEIN, J
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anticoagulants - therapeutic use
Biological and medical sciences
Bleeding
Blood Platelets - cytology
Bone marrow
Bone Marrow Transplantation - methods
Bone marrow, stem cells transplantation. Graft versus host reaction
Care and treatment
Case studies
Cohort Studies
Complications and side effects
Dosage and administration
Enoxaparin - pharmacology
Female
Hematologic and hematopoietic diseases
Hematopoietic stem cells
Hemorrhage - prevention & control
Heparin
Heparin, Low-Molecular-Weight - therapeutic use
Humans
Literature reviews
Male
Medical sciences
Methods
Middle Aged
Neoplasms - therapy
Physiological aspects
Platelet Count
Platelet diseases and coagulopathies
Platelets
Prognosis
Retrospective Studies
Safety
Stem cell transplantation
Stem Cell Transplantation - methods
Stem cells
Thrombocytopenia
Thrombocytopenia - therapy
Time Factors
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Transplantation
Weight
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Zusammenfassung:Few attempts have been made to examine the feasibility of safely administering low-molecular-weight-heparins (LMWHs) in the presence of concurrent thrombocytopenia. We retrospectively investigated the safety of low-dose LMWH in BMT patients, a population at risk of bleeding. In total, 26 patients received at least one dose of low-dose enoxaparin (ie
ISSN:0268-3369
1476-5365
DOI:10.1038/sj.bmt.1704952